Proteasomal and lysosomal protein degradation and heart disease

• Published in: Journal of molecular and cellular cardiology Vol. 71; pp. 16 - 24
• Main Authors: Wang, Xuejun, Robbins, Jeffrey
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.06.2014
• Subjects: Animals; Autophagy; Cardiovascular; Heart disease; Heart Diseases - metabolism; Humans; Lysosome; Lysosomes - metabolism; Proteasome; Proteasome Endopeptidase Complex - metabolism; Proteolysis; Ubiquitin; Ubiquitin - metabolism; Ubiquitin; Autophagy; Heart disease; Lysosome; Proteasome

In the cell, the proteasome and lysosomes represent the most important proteolytic machineries, responsible for the protein degradation in the ubiquitin–proteasome system (UPS) and autophagy, respectively. Both the UPS and autophagy are essential to protein quality and quantity control. Alterations...