Male-Enhanced Antigen Gene is Phylogenetically Conserved and Expressed at Late Stages of Spermatogenesis

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 86; no. 21; pp. 8462 - 8466
• Main Authors: Lau, Yun-Fai Chris, Chan, Kaimin, Sparkes, Robert
• Format: Journal Article
• Language: English
• Published: Washington, DC National Academy of Sciences of the United States of America 01.11.1989; National Acad Sciences
• Subjects: Amino Acid Sequence; Animals; Autoantigens; Base Sequence; Biological and medical sciences; Blotting, Northern; Blotting, Southern; Complementary DNA; Cosmids; DNA; DNA - genetics; DNA - isolation & purification; DNA probes; Female; Fundamental and applied biological sciences. Psychology; Genes; Genes. Genome; Genetic hybridization; Humans; Male; Membrane Proteins; Messenger RNA; Molecular and cellular biology; Molecular genetics; Molecular Sequence Data; Nucleic Acid Hybridization; Phylogeny; Proteins - genetics; RNA; Sequence Homology, Nucleic Acid; Space life sciences; Spermatogenesis; Testes; Testis - physiology; Transfection; Human; Molecular hybridization; Nucleotide sequence; Spermatogenesis; Interspecific comparison; In situ; Rodentia; Rabbit; Chromosome 6; Phylogeny; Lagomorpha; Genetic transfer; Characterization; Northern blotting; Vertebrata; Mammalia; Complementary DNA; Mouse; Isolation; Molecular cloning; Southern blotting

The male-enhanced antigen gene (Mea) was previously isolated from a mouse testicular cDNA library by using a pool of specific antisera against the serological H-Y antigen. The present studies characterize the human and mouse cDNAs and indicate that the MEA gene is conserved at both nucleic acid and...