Positive Selection of a Serine Residue in Bat IRF3 Confers Enhanced Antiviral Protection

• Published in: iScience Vol. 23; no. 3; p. 100958
• Main Authors: Banerjee, Arinjay, Zhang, Xi, Yip, Alyssa, Schulz, Katharina S., Irving, Aaron T., Bowdish, Dawn, Golding, Brian, Wang, Lin-Fa, Mossman, Karen
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 27.03.2020; Elsevier
• Subjects: Biological Sciences; Evolutionary Biology; Immunology; Evolutionary Biology; Biological Sciences; Immunology

Compared with other mammals, bats harbor more zoonotic viruses per species and do not demonstrate signs of disease on infection with these viruses. To counteract infections with viruses, bats have evolved enhanced mechanisms to limit virus replication and immunopathology. However, molecular and cell...