Potential mechanisms for the hypothesized link between sunshine, vitamin D, and food allergy in children

• Published in: Journal of allergy and clinical immunology Vol. 126; no. 2; pp. 217 - 222
• Main Authors: Vassallo, Milo F., Camargo, Carlos A.
• Format: Journal Article
• Language: English
• Published: United States Mosby, Inc 01.08.2010; Elsevier Limited
• Subjects: Allergens - immunology; Allergens - metabolism; Allergies; Allergy and Immunology; atopy; Child; Child, Preschool; Dietary supplements; Disease; epithelial barrier; Epithelium - immunology; Epithelium - metabolism; Epithelium - physiopathology; Female; Food; Food allergies; Food allergy; Food Hypersensitivity - epidemiology; Food Hypersensitivity - immunology; Food Hypersensitivity - metabolism; Food Hypersensitivity - physiopathology; Gastrointestinal Diseases - epidemiology; Gastrointestinal Diseases - immunology; Gastrointestinal Diseases - metabolism; Gastrointestinal Diseases - physiopathology; Human subjects; Humans; Hygiene; Hypotheses; Immune Tolerance - immunology; Immune Tolerance - radiation effects; Immunity, Mucosal - immunology; Immunity, Mucosal - radiation effects; Infections; Male; Metabolites; microbial ecology; Models, Theoretical; mucosal immunity; Obesity; Older people; Risk factors; sensitization; Sunlight; Trends; Ultraviolet Rays; Vitamin D; Vitamin D - immunology; Vitamin D - metabolism; vitamin D deficiency; Vitamin D Deficiency - epidemiology; Vitamin D Deficiency - immunology; Vitamin D Deficiency - metabolism; Vitamin D Deficiency - physiopathology; Vitamin deficiency; United States > US; UVB; Food allergy; vitamin D; Treg; atopy; microbial ecology; vitamin D deficiency; epithelial barrier; VDD; infections; 25(OH)D; sensitization; FA; mucosal immunity; T regulatory cell; Ultraviolet B solar radiation; 25-Hydroxyvitamin D

Epidemiologic data suggest that the incidence of food allergy (FA) is increasing among children, yet a satisfactory model of its pathogenesis remains elusive. FA is the consequence of maladaptive immune responses to common and otherwise innocuous food antigens. Concurrent with the increase in FA is...