Zika Virus Infection during Pregnancy in Mice Causes Placental Damage and Fetal Demise

• Published in: Cell Vol. 165; no. 5; pp. 1081 - 1091
• Main Authors: Miner, Jonathan J., Cao, Bin, Govero, Jennifer, Smith, Amber M., Fernandez, Estefania, Cabrera, Omar H., Garber, Charise, Noll, Michelle, Klein, Robyn S., Noguchi, Kevin K., Mysorekar, Indira U., Diamond, Michael S.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 19.05.2016
• Subjects: abortion (animals); animal models; Animals; antibodies; Apoptosis; brain; Brain - embryology; Brain - pathology; Brain - virology; congenital abnormalities; Disease Models, Animal; Female; females; fetal death; Fetal Diseases - pathology; Fetal Diseases - virology; fetus; heterozygosity; humans; interferons; Male; males; Mice; Mice, Inbred C57BL; pathogenesis; placenta; Placenta Diseases - pathology; Placenta Diseases - virology; Pregnancy; Pregnancy Complications, Infectious - pathology; Pregnancy Complications, Infectious - virology; pregnant women; Receptor, Interferon alpha-beta - genetics; Receptor, Interferon alpha-beta - metabolism; RNA, Viral - isolation & purification; vaccines; Zika virus; Zika Virus - physiology; Zika Virus Infection - pathology; Zika Virus Infection - virology

Zika virus (ZIKV) infection in pregnant women causes intrauterine growth restriction, spontaneous abortion, and microcephaly. Here, we describe two mouse models of placental and fetal disease associated with in utero transmission of ZIKV. Female mice lacking type I interferon signaling (Ifnar1−/−) c...