Identification of phosphodiesterase-4 as the therapeutic target of arctigenin in alleviating psoriatic skin inflammation

• Published in: Journal of advanced research Vol. 33; pp. 241 - 251
• Main Authors: Li, Heng, Zhang, Xianglei, Xiang, Caigui, Feng, Chunlan, Fan, Chen, Liu, Moting, Lu, Huimin, Su, Haixia, Zhou, Yu, Qi, Qing, Xu, Yechun, Tang, Wei
• Format: Journal Article
• Language: English
• Published: Egypt Elsevier B.V 01.11.2021; Elsevier
• Subjects: Animals; Arctigenin; Cyclic Nucleotide Phosphodiesterases, Type 4; Furans; Humans; Inflammation; Inflammation - chemically induced; Inflammation - drug therapy; Leukocytes, Mononuclear; Lignans - pharmacology; Lignans - therapeutic use; Mice; Original; PDE4; Psoriasis; Arctigenin; Inflammation; Psoriasis; PDE4

Arctigenin, derived from Arctium lappa L., has multiple pharmacological activities, including immunoregulatory, anti-diabetic, anti-tumor, and neuroprotective effects. Nevertheless, the potential therapeutic target of arctigenin in modulating inflammation remains undefined. In the present study, we...