Peripheral Cannabinoid-1 Receptor Inverse Agonism Reduces Obesity by Reversing Leptin Resistance - Tam, Joseph; Cinar, Resat; Liu, Jie; Godlewski, Grzegorz; Wesley, Daniel; Jourdan, Tony; Szanda, Gergő; Mukhopadhyay, Bani; Chedester, Lee; Liow, Jeih-San; Innis, Robert B.; Cheng, Kejun; et al. (Cell metabolism, 2012)
Keywords: adipocytes; Adipocytes - metabolism; agonistic behavior; agonists; Animals; Anti-Obesity Agents - chemistry; Anti-Obesity Agents - pharmacology; Anti-Obesity Agents - therapeutic use; appetite; Body Weight - drug effects; Drug Inverse Agonism; Drug Resistance - drug effects; energy expenditure; fatty liver; Fatty Liver - drug therapy; Fatty Liver - etiology; Insulin Resistance; kidneys; leptin; Leptin - metabolism; Mice; Molecular Structure; obesity; Obesity - complications; Obesity - drug therapy; Obesity - metabolism; Pyrazoles - chemistry; Pyrazoles - pharmacology; Pyrazoles - therapeutic use; Receptor, Cannabinoid, CB1 - agonists; Regression Analysis; risk; secretion; Sulfonamides - chemistry; Sulfonamides - pharmacology; Sulfonamides - therapeutic use; weight loss