Mitochondrial quality control mechanisms as molecular targets in cardiac ischemia–reperfusion injury

• Published in: Acta pharmaceutica Sinica. B Vol. 10; no. 10; pp. 1866 - 1879
• Main Authors: Wang, Jin, Zhou, Hao
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.10.2020; Elsevier
• Subjects: Apoptosis; Cardiomyocyte I/R injury; Fusion; Mitochondrial death; Mitochondrial fission; Mitochondrial quality control; Mitophagy; Necroptosis; Review; Necroptosis; Mitophagy; Mitochondrial fission; Fusion; Mitochondrial quality control; Mitochondrial death; Cardiomyocyte I/R injury; Apoptosis

Mitochondrial damage is a critical contributor to cardiac ischemia/reperfusion (I/R) injury. Mitochondrial quality control (MQC) mechanisms, a series of adaptive responses that preserve mitochondrial structure and function, ensure cardiomyocyte survival and cardiac function after I/R injury. MQC inc...