Rare independent mutations in renal salt handling genes contribute to blood pressure variation - Ji, Weizhen; Foo, Jia Nee; O'Roak, Brian J; Zhao, Hongyu; Larson, Martin G; Simon, David B; Newton-Cheh, Christopher; State, Matthew W; Levy, Daniel; Lifton, Richard P (Nature genetics, 2008)
Keywords: Adult; Agriculture; Amino Acid Sequence; Amino Acid Substitution; Amino acids; Animal Genetics and Genomics; Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; Blood pressure; Blood Pressure - genetics; Cancer Research; Cohort Studies; Female; Fundamental and applied biological sciences. Psychology; Gene Function; Gene mutations; Genes; Genetic aspects; Genetic testing; Genetics; Genetics of eukaryotes. Biological and molecular evolution; Health aspects; Heart attacks; Heart failure; Heterozygote; Human Genetics; Humans; Hypertension; Hypertension - epidemiology; Hypertension - genetics; Kidney - metabolism; Male; Middle Aged; Molecular Sequence Data; Mutation; Potassium Channels, Inwardly Rectifying - genetics; Prevalence; Receptors, Drug - genetics; Risk factors; Sodium Chloride - metabolism; Sodium-Potassium-Chloride Symporters - genetics; Solute Carrier Family 12, Member 1; Solute Carrier Family 12, Member 3; Studies; Symporters - genetics; United States; Blood pressure; Hemodynamics; Mutation; Urinary system; Gene; Kidney