Tissue-Specific mRNA Expression Profiles of Drug-Metabolizing Enzymes and Transporters in the Cynomolgus Monkey

Pairs of forward and reverse primers and TaqMan probes specific to each of 19 drug-metabolizing enzymes (cytochrome P450s, UDP-glucuronosyltransferases, glutathione S-transferases, and sulfotransferases) and 5 transporters (ABC and SLC transporters) in the cynomolgus monkey were prepared. The expres...

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Published inDRUG METABOLISM AND PHARMACOKINETICS Vol. 24; no. 2; pp. 139 - 144
Main Authors Nishimura, Masuhiro, Koeda, Akiko, Morikawa, Hiroshi, Satoh, Tetsuo, Narimatsu, Shizuo, Naito, Shinsaku
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.01.2009
Japanese Society for the Study of Xenobiotics
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Abstract Pairs of forward and reverse primers and TaqMan probes specific to each of 19 drug-metabolizing enzymes (cytochrome P450s, UDP-glucuronosyltransferases, glutathione S-transferases, and sulfotransferases) and 5 transporters (ABC and SLC transporters) in the cynomolgus monkey were prepared. The expression level of each target mRNA was analyzed in total RNA obtained from three specimens of various cynomolgus monkey tissues (adrenal gland, brain, heart, kidney, large intestine, liver, lung, pancreas, prostate, small intestine, spleen, testis, and thymus) by real-time reverse transcription PCR using an Applied Biosystems 7500 Fast Real-Time PCR System. The data obtained in the present study provide useful information on tissue-specific profiles of the expression of these target mRNAs in the cynomolgus monkey, and the results are expected to be valuable in establishing drug metabolism- and transporter-mediated screening systems using the cynomolgus monkey for the evaluation of new chemical entities in new drug development.
AbstractList Pairs of forward and reverse primers and TaqMan probes specific to each of 19 drug-metabolizing enzymes (cytochrome P450s, UDP-glucuronosyltransferases, glutathione S-transferases, and sulfotransferases) and 5 transporters (ABC and SLC transporters) in the cynomolgus monkey were prepared. The expression level of each target mRNA was analyzed in total RNA obtained from three specimens of various cynomolgus monkey tissues (adrenal gland, brain, heart, kidney, large intestine, liver, lung, pancreas, prostate, small intestine, spleen, testis, and thymus) by real-time reverse transcription PCR using an Applied Biosystems 7500 Fast Real-Time PCR System. The data obtained in the present study provide useful information on tissue-specific profiles of the expression of these target mRNAs in the cynomolgus monkey, and the results are expected to be valuable in establishing drug metabolism- and transporter-mediated screening systems using the cynomolgus monkey for the evaluation of new chemical entities in new drug development.
[Summary]:Pairs of forward and reverse primers and TaqMan probes specific to each of 19 drug-metabolizing enzymes (cytochrome P450s, UDP-glucuronosyltransferases, glutathione S-transferases, and sulfotransferases) and 5 transporters (ABC and SLC transporters) in the cynomolgus monkey were prepared. The expression level of each target mRNA was analyzed in total RNA obtained from three specimens of various cynomolgus monkey tissues (adrenal gland, brain, heart, kidney, large intestine, liver, lung, pancreas, prostate, small intestine, spleen, testis, and thymus) by real-time reverse transcription PCR using an Applied Biosystems 7500 Fast Real-Time PCR System. The data obtained in the present study provide useful information on tissue-specific profiles of the expression of these target mRNAs in the cynomolgus monkey, and the results are expected to be valuable in establishing drug metabolism- and transporter-mediated screening systems using the cynomolgus monkey for the evaluation of new chemical entities in new drug development.
Author Morikawa, Hiroshi
Satoh, Tetsuo
Naito, Shinsaku
Nishimura, Masuhiro
Koeda, Akiko
Narimatsu, Shizuo
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Issue 2
Keywords cynomolgus monkey
quantification
drug-metabolizing enzymes
mRNA expression
tissue distribution
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Snippet Pairs of forward and reverse primers and TaqMan probes specific to each of 19 drug-metabolizing enzymes (cytochrome P450s, UDP-glucuronosyltransferases,...
[Summary]:Pairs of forward and reverse primers and TaqMan probes specific to each of 19 drug-metabolizing enzymes (cytochrome P450s,...
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SubjectTerms Animals
ATP-Binding Cassette Transporters - genetics
ATP-Binding Cassette Transporters - metabolism
ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism
Cells, Cultured
cynomolgus monkey
Cytochrome P-450 CYP3A - metabolism
DNA Probes
Dose-Response Relationship, Drug
drug-metabolizing enzymes
Gene Expression
Gene Expression Profiling
Glutathione Transferase - genetics
Glutathione Transferase - metabolism
Inactivation, Metabolic
Macaca fascicularis
Male
Membrane Transport Proteins - metabolism
Microsomes, Liver - enzymology
mRNA expression
quantification
Reverse Transcriptase Polymerase Chain Reaction
RNA, Messenger - metabolism
Species Specificity
Tissue Distribution
Title Tissue-Specific mRNA Expression Profiles of Drug-Metabolizing Enzymes and Transporters in the Cynomolgus Monkey
URI https://dx.doi.org/10.2133/dmpk.24.139
http://mol.medicalonline.jp/library/journal/download?GoodsID=co1metab/2009/002402/003&name=0139-0144e
https://www.ncbi.nlm.nih.gov/pubmed/19430169
Volume 24
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