Alternate RASSF1 Transcripts Control SRC Activity, E-Cadherin Contacts, and YAP-Mediated Invasion

• Published in: Current biology Vol. 25; no. 23; pp. 3019 - 3034
• Main Authors: Vlahov, Nikola, Scrace, Simon, Soto, Manuel Sarmiento, Grawenda, Anna M., Bradley, Leanne, Pankova, Daniela, Papaspyropoulos, Angelos, Yee, Karen S., Buffa, Francesca, Goding, Colin R., Timpson, Paul, Sibson, Nicola, O’Neill, Eric
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 07.12.2015; Cell Press
• Subjects: Adaptor Proteins, Signal Transducing - genetics; Adaptor Proteins, Signal Transducing - metabolism; Cadherins - genetics; Cadherins - metabolism; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Gene Expression Regulation, Neoplastic; Humans; Phosphoproteins - genetics; Phosphoproteins - metabolism; Protein Kinases - genetics; Protein Kinases - metabolism; Signal Transduction; Transcription Factors; Transcriptional Activation; Tumor Suppressor Proteins - genetics; Tumor Suppressor Proteins - metabolism; YAP-Signaling Proteins

Tumor progression to invasive carcinoma is associated with activation of SRC family kinase (SRC, YES, FYN) activity and loss of cellular cohesion. The hippo pathway-regulated cofactor YAP1 supports the tumorigenicity of RAS mutations but requires both inactivation of hippo signaling and YES-mediated...