ALDH1A3 Regulations of Matricellular Proteins Promote Vascular Smooth Muscle Cell Proliferation

• Published in: iScience Vol. 19; pp. 872 - 882
• Main Authors: Xie, Xiujie, Urabe, Go, Marcho, Lynn, Stratton, Matthew, Guo, Lian-Wang, Kent, Craig K.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 27.09.2019; Elsevier
• Subjects: Molecular Biology; Molecular Mechanism of Behavior; Pathophysiology; Vascular Remodeling; Vascular Remodeling; Pathophysiology; Molecular Biology; Molecular Mechanism of Behavior

Vascular smooth muscle cell (VSMC) proliferation promotes intimal hyperplasia (IH) in occluding vascular diseases. Here we identified a positive role of ALDH1A3 (an aldehyde dehydrogenase) in this pro-IH process. The expression of ALDH1A3, but not that of 18 other isoforms of the ALDH family, was su...