The gut microbiome: an orchestrator of xenobiotic metabolism - Collins, Stephanie L.; Patterson, Andrew D. (Acta pharmaceutica Sinica. B, 2020)
Keywords: Absorption; Bioactivation; Enterohepatic circulation; Gastrointestinal tract; Gut microbiome; Pharmacokinetics; Review; Xenobiotic metabolism; BVU; FXR; BDE; UGT; Bioactivation; NSAID; TUDCA; BRV; Xenobiotic metabolism; AHR; PXR; SULT; cgr; SN-38G; Absorption; PABA; TCDF; CYP; GF; GUDCA; Gastrointestinal tract; ER; SCFA; PCB; ALDH; CV; PD; Enterohepatic circulation; CAR; PAH; 5-ASA; Pharmacokinetics; Gut microbiome; 5-FU; PFOS; cgr, cytochrome glycoside reductase; BDE, bromodiphenyl ether; CV, conventional; PCB, polychlorinated biphenyl; ER, estrogen receptor; PFOS, perfluorooctanesulfonic acid; ALDH, aldehyde dehydrogenase; GUDCA, glycoursodeoxycholic acid; SCFA, short chain fatty acid; 5-FU, 5-fluorouracil; SULT, sulfotransferase; PXR, pregnane X receptor; TCDF, 2,3,7,8-tetrachlorodibenzofuran; GF, germ-free; CAR, constitutive androgen receptor; CYP, cytochrome P450; NSAID, non-steroidal anti-inflammatory drug; FXR, farnesoid X receptor; SN-38G, SN-38 glucuronide; BRV, brivudine; PAH, polycyclic aromatic hydrocarbon; 5-ASA, 5-aminosalicylic acid; UGT, uracil diphosphate-glucuronosyltransferase; AHR, aryl Hydrocarbon Receptor; TUDCA, tauroursodeoxycholic acid; PD, Parkinson's disease; BVU, bromovinyluracil; PABA, p-aminobenzenesulphonamide