SMARCAD1 Phosphorylation and Ubiquitination Are Required for Resection during DNA Double-Strand Break Repair

• Published in: iScience Vol. 2; pp. 123 - 135
• Main Authors: Chakraborty, Sharmistha, Pandita, Raj K., Hambarde, Shashank, Mattoo, Abid R., Charaka, Vijaya, Ahmed, Kazi M., Iyer, Swaminathan P., Hunt, Clayton R., Pandita, Tej K.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 27.04.2018; Elsevier
• Subjects: Bioengineering; In Vitro Toxicology Including 3D Culture; Tissue Engineering; Bioengineering; In Vitro Toxicology Including 3D Culture; Tissue Engineering

The chromatin remodeling factor SMARCAD1, an SWI/SNF ATPase family member, has a role in 5′ end resection at DNA double-strand breaks (DSBs) to produce single-strand DNA (ssDNA), a critical step for subsequent checkpoint and repair factor loading to remove DNA damage. However, the mechanistic detail...