Comparison of two different methods of image analysis for the assessment of microglial activation in patients with multiple sclerosis using (R)-[N-methyl-carbon-11]PK11195

• Published in: PloS one Vol. 13; no. 8; p. e0201289
• Main Authors: Kang, Yeona, Schlyer, David, Kaunzner, Ulrike W., Kuceyeski, Amy, Kothari, Paresh J., Gauthier, Susan A.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 09.08.2018; Public Library of Science (PLoS)
• Subjects: 60 APPLIED LIFE SCIENCES; Activation analysis; Adult; Binding; Binding sites; Biology and Life Sciences; Brain; Brain - cytology; Brain - diagnostic imaging; Brain - pathology; Care and treatment; Central nervous system; Cluster analysis; Clustering; Comparative analysis; Cortex; Female; Graphical methods; Human subjects; Humans; Image analysis; Image processing; Image Processing, Computer-Assisted - methods; Immune response; Immune system; Innate immunity; Isoquinolines - administration & dosage; Isoquinolines - chemistry; Lesions; Macrophages; Magnetic resonance imaging; Magnetic Resonance Imaging - methods; Male; Masks; Medical imaging; Medicine and Health Sciences; Methods; Microglia; Microglia - immunology; Microglia - pathology; Middle Aged; Multiple sclerosis; Multiple Sclerosis, Chronic Progressive - diagnostic imaging; Multiple Sclerosis, Chronic Progressive - immunology; Multiple Sclerosis, Chronic Progressive - pathology; Neuroimaging; Nuclear medicine; Patients; Physical Sciences; Positron emission; Positron emission tomography; Positron-Emission Tomography - methods; Radiopharmaceuticals - administration & dosage; Radiopharmaceuticals - chemistry; Reproducibility of Results; Research and Analysis Methods; Science & Technology - Other Topics; Substantia alba; Substantia grisea; Thalamus; Therapeutic applications; Tomography; New York; United States > US

Chronic active multiple sclerosis (MS) lesions have a rim of activated microglia/macrophages (m/M) leading to ongoing tissue damage, and thus represent a potential treatment target. Activation of this innate immune response in MS has been visualized and quantified using PET imaging with [11C]-(R)-PK...