Tuning Electrostatic Gating of Semiconducting Carbon Nanotubes by Controlling Protein Orientation in Biosensing Devices

• Published in: Angewandte Chemie International Edition Vol. 60; no. 37; pp. 20184 - 20189
• Main Authors: Xu, Xinzhao, Bowen, Benjamin J., Gwyther, Rebecca E. A., Freeley, Mark, Grigorenko, Bella, Nemukhin, Alexander V., Eklöf‐Österberg, Johnas, Moth‐Poulsen, Kasper, Jones, D. Dafydd, Palma, Matteo
• Format: Journal Article
• Language: English
• Published: Weinheim Wiley Subscription Services, Inc 06.09.2021; John Wiley and Sons Inc
• Edition: International ed. in English
• Subjects: Antimicrobial agents; Antimicrobial resistance; Biosensors; Carbon nanotubes; Communication; Communications; Conductance; Debye length; Electrostatic properties; Field effect transistors; Gating; Nanotechnology; Nanotubes; protein engineering; protein orientation; Proteins; Semiconductor devices

The ability to detect proteins through gating conductance by their unique surface electrostatic signature holds great potential for improving biosensing sensitivity and precision. Two challenges are: (1) defining the electrostatic surface of the incoming ligand protein presented to the conductive su...