Characterizing the role of miRNAs within gene regulatory networks using integrative genomics techniques

• Published in: Molecular systems biology Vol. 7; no. 1; pp. 490 - n/a
• Main Authors: Su, Wan‐Lin, Kleinhanz, Robert R, Schadt, Eric E
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 24.05.2011; John Wiley & Sons, Ltd; EMBO Press; Nature Publishing Group; Springer Nature
• Subjects: Animals; Biological activity; causal associations; Control theory; EMBO09; eQTL mapping; expression QTL; Fat metabolism; Feedback; Feedback loops; Gene expression; Gene Expression Profiling; Gene Regulatory Networks; Genetic diversity; Genetic Linkage; Genetics; Genomics; Genotypes; High-Throughput Screening Assays; Hypotheses; Liver; Loci; Male; Metabolism; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Transgenic; microRNA; MicroRNAs; MicroRNAs - genetics; MicroRNAs - metabolism; miRNA; Molecular chains; Networks; Nodes; Oligonucleotide Array Sequence Analysis; Phenotypes; Quantitative Trait Loci; Ribonucleic acid; RNA; RNA, Messenger - genetics; RNA, Messenger - metabolism; Sensors; Transcription; causal associations; expression QTL; microRNA; eQTL mapping

Integrative genomics and genetics approaches have proven to be a useful tool in elucidating the complex relationships often found in gene regulatory networks. More importantly, a number of studies have provided the necessary experimental evidence confirming the validity of the causal relationships i...