Array comparative genomic hybridization in retinoma and retinoblastoma tissues

• Published in: Cancer science Vol. 100; no. 3; pp. 465 - 471
• Main Authors: Sampieri, Katia, Amenduni, Mariangela, Papa, Filomena Tiziana, Katzaki, Eleni, Mencarelli, Maria Antonietta, Marozza, Annabella, Epistolato, Maria Carmela, Toti, Paolo, Lazzi, Stefano, Bruttini, Mirella, De Filippis, Roberta, De Francesco, Sonia, Longo, Ilaria, Meloni, Ilaria, Mari, Francesca, Acquaviva, Antonio, Hadjistilianou, Theodora, Renieri, Alessandra, Ariani, Francesca
• Format: Journal Article
• Language: English
• Published: Melbourne, Australia Blackwell Publishing Asia 01.03.2009; Blackwell
• Subjects: Age of Onset; Antibodies, Anti-Idiotypic; Biological and medical sciences; Child, Preschool; Comparative Genomic Hybridization; DNA Mutational Analysis; Genes, Retinoblastoma; Humans; Image Processing, Computer-Assisted; Infant; Lasers; Medical sciences; Microdissection; Mutation; Ophthalmology; Original; Retinal Neoplasms - genetics; Retinal Neoplasms - pathology; Retinoblastoma - genetics; Retinoblastoma - pathology; Retinoblastoma Protein - genetics; Tumors; Tumors and pseudotumors of the eye, orbit, eyelid, lacrimal apparatus; Human; Eye disease; Nervous system diseases; Retinopathy; Cancerology; Comparative genomic hybridization; Malignant tumor; Gene expression; Retinoblastoma; Child; Cancer

In retinoblastoma, two RB1 mutations are necessary for tumor development. Recurrent genomic rearrangements may represent subsequent events required for retinoblastoma progression. Array‐comparative genomic hybridization was carried out in 18 eye samples, 10 from bilateral and eight from unilateral r...