p16基因在膀胱肿瘤细胞凋亡中的作用
R737.14%Q786; 目的 探讨p16基因与膀胱肿瘤细胞凋亡的关系.方法 应用SABC免疫组织化学法检测了51例膀胱移行细胞癌p16基因的表达,同时用流式细胞仪检测其细胞凋亡情况.结果 p16阳性表达率为47.1%(24/51),平均凋亡肿瘤细胞百分比为1.5%,p16阳性表达的肿瘤组织凋亡细胞百分比＞1.5%的发生率为62.5%,p16阴性表达的肿瘤组织凋亡细胞百分比＞1.5%的发生率为25.9%,两者比较有显著性差异(P＜0.01).结论 p16基因的表达与膀胱肿瘤细胞凋亡有关,p16基因可能参与膀胱肿瘤细胞凋亡的正向调节作用....
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| Published in | 肿瘤防治研究 Vol. 27; no. 2; pp. 97 - 98 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | Chinese |
| Published |
430079武汉,湖北省肿瘤医院腹泌外科%湖北医科大学附属一医院%430079武汉,湖北省肿瘤医院放疗科
2000
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1000-8578 |
| DOI | 10.3971/j.issn.1000-8578.2000.02.007 |
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| Abstract | R737.14%Q786; 目的 探讨p16基因与膀胱肿瘤细胞凋亡的关系.方法 应用SABC免疫组织化学法检测了51例膀胱移行细胞癌p16基因的表达,同时用流式细胞仪检测其细胞凋亡情况.结果 p16阳性表达率为47.1%(24/51),平均凋亡肿瘤细胞百分比为1.5%,p16阳性表达的肿瘤组织凋亡细胞百分比＞1.5%的发生率为62.5%,p16阴性表达的肿瘤组织凋亡细胞百分比＞1.5%的发生率为25.9%,两者比较有显著性差异(P＜0.01).结论 p16基因的表达与膀胱肿瘤细胞凋亡有关,p16基因可能参与膀胱肿瘤细胞凋亡的正向调节作用. |
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| AbstractList | R737.14%Q786; 目的 探讨p16基因与膀胱肿瘤细胞凋亡的关系.方法 应用SABC免疫组织化学法检测了51例膀胱移行细胞癌p16基因的表达,同时用流式细胞仪检测其细胞凋亡情况.结果 p16阳性表达率为47.1%(24/51),平均凋亡肿瘤细胞百分比为1.5%,p16阳性表达的肿瘤组织凋亡细胞百分比＞1.5%的发生率为62.5%,p16阴性表达的肿瘤组织凋亡细胞百分比＞1.5%的发生率为25.9%,两者比较有显著性差异(P＜0.01).结论 p16基因的表达与膀胱肿瘤细胞凋亡有关,p16基因可能参与膀胱肿瘤细胞凋亡的正向调节作用. |
| Author | 魏少忠 张克亮 谈凯 程志斌 陈继红 李长青 |
| AuthorAffiliation | 430079武汉,湖北省肿瘤医院腹泌外科%湖北医科大学附属一医院%430079武汉,湖北省肿瘤医院放疗科 |
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| DocumentTitle_FL | Effect of p16 Gene on the Apoptosis of Bladder Carcinoma Cells |
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| Keywords | 膀胱肿瘤 流式细胞仪 p16基因 |
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| Snippet | R737.14%Q786; 目的 探讨p16基因与膀胱肿瘤细胞凋亡的关系.方法 应用SABC免疫组织化学法检测了51例膀胱移行细胞癌p16基因的表达,同时用流式细胞仪检测其细胞凋亡情况.结果... |
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| Title | p16基因在膀胱肿瘤细胞凋亡中的作用 |
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