T 2 Clusters Are More Sensitive Than Mean T 2 Change to Detect Early and Longitudinal Changes in Anterior Cruciate Ligament Reconstructed and Healthy Knees

• Published in: Journal of magnetic resonance imaging Vol. 61; no. 6; pp. 2615 - 2629
• Main Authors: Pai S, Anoosha, Gatti, Anthony A., Black, Marianne S., Young, Katherine A., Desai, Arjun D., Barbieri, Marco, Asay, Jessica L., Sherman, Seth L., Gold, Garry E., Kogan, Feliks, Hargreaves, Brian A., Chaudhari, Akshay S.
• Format: Journal Article
• Language: English
• Published: United States 01.06.2025
• Subjects: Adult; Anterior Cruciate Ligament - diagnostic imaging; Anterior Cruciate Ligament - surgery; Anterior Cruciate Ligament Injuries - diagnostic imaging; Anterior Cruciate Ligament Reconstruction; Cartilage, Articular - diagnostic imaging; Case-Control Studies; Cluster Analysis; Female; Humans; Imaging, Three-Dimensional; Knee - diagnostic imaging; Knee Joint - diagnostic imaging; Longitudinal Studies; Magnetic Resonance Imaging - methods; Male; Middle Aged; Osteoarthritis, Knee - diagnostic imaging; post‐traumatic osteoarthritis; ACL‐reconstruction; T2 relaxometry; cluster analysis; femoral cartilage

Post-traumatic osteoarthritis (PTOA) often follows anterior cruciate ligament reconstruction (ACLR), leading to early cartilage degradation. Change in mean T fails to capture subject-specific spatial-temporal variations, highlighting the need for robust quantitative methods for early PTOA detection...