Interaction between IL13 genotype and environmental factors in the risk for allergic rhinitis in Korean children

• Published in: Journal of allergy and clinical immunology Vol. 130; no. 2; pp. 421 - 426.e5
• Main Authors: Kim, Woo Kyung, Kwon, Ji-Won, Seo, Ju-Hee, Kim, Hyung Young, Yu, Jinho, Kim, Byoung-Ju, Kim, Hyo-Bin, Lee, So Yeon, Kim, Kyung Won, Kang, Mi-Jin, Shin, Yee-Jin, Hong, Soo-Jong
• Format: Journal Article
• Language: English
• Published: New York, NY Mosby, Inc 01.08.2012; Elsevier; Elsevier Limited
• Subjects: Age; Allergens - immunology; Allergic diseases; Allergic rhinitis; Allergies; Allergy and Immunology; Antibiotics; Asthma; Biological and medical sciences; Child; childhood; Children; Construction Materials - adverse effects; Data processing; Deoxyribonucleic acid; Disease; DNA; elementary students; Environment. Living conditions; environmental exposure; Environmental Exposure - adverse effects; Environmental factors; Families & family life; Family medical history; Female; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Fungi - immunology; gene-environment interaction; Genetic Predisposition to Disease; Genetic testing; Genetics; genotype; Genotype & phenotype; Genotypes; Houses; Housing; Humans; Hypersensitivity; IL-13 polymorphism; Immunopathology; infancy; Infant; Infants; Interleukin 1; Interleukin 13; Interleukin-13 - genetics; Interleukin-13 - immunology; Inventories; Korean Peninsula; Koreans; Logistics; Male; Medical sciences; Molds; Nucleotides; Odds Ratio; parents; Parents & parenting; Polymorphism; Polymorphism, Genetic; Prevalence; Public health. Hygiene; Public health. Hygiene-occupational medicine; Questionnaires; Republic of Korea - epidemiology; Respiratory diseases; Rhinitis; Rhinitis, Allergic, Perennial - epidemiology; Rhinitis, Allergic, Perennial - etiology; Rhinitis, Allergic, Perennial - genetics; Rhinitis, Allergic, Perennial - immunology; risk factor; Risk Factors; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; school children; Smoke - adverse effects; Students; Studies; Surveys and Questionnaires; Asia; Korea; Republic of Korea; Korea, Rep., Seoul; Korean Peninsula; prevalence; AR; ISAAC; IL-13 polymorphism; OR; SNP; aOR; Allergic rhinitis; gene-environment interaction; infancy; risk factor; Adjusted odd ratio; International Study of Asthma and Allergies in Childhood; Odds ratio; Single nucleotide polymorphism; Allergy; Nose disease; Prevalence; Genetic variability; Rhinitis; Environmental factor; Infant; Risk; Epidemiology; Immunology; Health and environment; ENT disease; Child; Human; Immunopathology; Typing; Cytokine; Genotype; Interleukin 13; Genotype environment interaction; Risk factor; Environment; Polymorphism

The prevalence of allergic rhinitis (AR) is increasing worldwide. Allergic diseases develop in susceptible subjects when they are exposed to specific environmental factors. We analyzed changes in the prevalence of AR and identified genetic and environmental factors in early childhood that affect ris...