Interaction between IL13 genotype and environmental factors in the risk for allergic rhinitis in Korean children
The prevalence of allergic rhinitis (AR) is increasing worldwide. Allergic diseases develop in susceptible subjects when they are exposed to specific environmental factors. We analyzed changes in the prevalence of AR and identified genetic and environmental factors in early childhood that affect ris...
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| Published in | Journal of allergy and clinical immunology Vol. 130; no. 2; pp. 421 - 426.e5 |
|---|---|
| Main Authors | , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
New York, NY
Mosby, Inc
01.08.2012
Elsevier Elsevier Limited |
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| Online Access | Get full text |
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| Abstract | The prevalence of allergic rhinitis (AR) is increasing worldwide. Allergic diseases develop in susceptible subjects when they are exposed to specific environmental factors.
We analyzed changes in the prevalence of AR and identified genetic and environmental factors in early childhood that affect risk.
We used the International Study of Asthma and Allergies in Childhood questionnaire to collect data on AR, allergies, and environmental exposures from 4554 elementary school students from 5 areas of Seoul, Korea, in 2008. We also obtained DNA from 1050 subjects from 1 area of Seoul for genotype analysis of IL13.
We identified genetic and environmental factors during infancy and early childhood that increased the risk for current AR (resulting in a diagnosis of AR and AR symptoms in the past 12 months) in elementary school–aged children. These included allergic disease in parents and antibiotic use in infants, allergic disease in parents and exposure of infants to mold, and allergic disease in parents and moving an infant to a newly built house. The risk of current AR also increased in subjects with GA or AA at nucleotide 2044 in IL13 who had been exposed to mold in the home during infancy (adjusted odds ratio, 3.27; 95% CI, 1.75-6.11) compared with subjects who had GG at this position and had not been exposed to mold (adjusted odds ratio, 3.27; 95% CI, 1.75-6.11).
The prevalence of AR is increasing in Korean children. Children with a family history of allergic disease and exposure to specific environmental risk factors during infancy are more likely to have AR. Children with GA or AA at IL13(+2044) are at increased risk for AR when exposed to mold in the home during the first year of life. |
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| AbstractList | The prevalence of allergic rhinitis (AR) is increasing worldwide. Allergic diseases develop in susceptible subjects when they are exposed to specific environmental factors.
We analyzed changes in the prevalence of AR and identified genetic and environmental factors in early childhood that affect risk.
We used the International Study of Asthma and Allergies in Childhood questionnaire to collect data on AR, allergies, and environmental exposures from 4554 elementary school students from 5 areas of Seoul, Korea, in 2008. We also obtained DNA from 1050 subjects from 1 area of Seoul for genotype analysis of IL13.
We identified genetic and environmental factors during infancy and early childhood that increased the risk for current AR (resulting in a diagnosis of AR and AR symptoms in the past 12 months) in elementary school–aged children. These included allergic disease in parents and antibiotic use in infants, allergic disease in parents and exposure of infants to mold, and allergic disease in parents and moving an infant to a newly built house. The risk of current AR also increased in subjects with GA or AA at nucleotide 2044 in IL13 who had been exposed to mold in the home during infancy (adjusted odds ratio, 3.27; 95% CI, 1.75-6.11) compared with subjects who had GG at this position and had not been exposed to mold (adjusted odds ratio, 3.27; 95% CI, 1.75-6.11).
The prevalence of AR is increasing in Korean children. Children with a family history of allergic disease and exposure to specific environmental risk factors during infancy are more likely to have AR. Children with GA or AA at IL13(+2044) are at increased risk for AR when exposed to mold in the home during the first year of life. BACKGROUND: The prevalence of allergic rhinitis (AR) is increasing worldwide. Allergic diseases develop in susceptible subjects when they are exposed to specific environmental factors. OBJECTIVE: We analyzed changes in the prevalence of AR and identified genetic and environmental factors in early childhood that affect risk. METHODS: We used the International Study of Asthma and Allergies in Childhood questionnaire to collect data on AR, allergies, and environmental exposures from 4554 elementary school students from 5 areas of Seoul, Korea, in 2008. We also obtained DNA from 1050 subjects from 1 area of Seoul for genotype analysis of IL13. RESULTS: We identified genetic and environmental factors during infancy and early childhood that increased the risk for current AR (resulting in a diagnosis of AR and AR symptoms in the past 12 months) in elementary school–aged children. These included allergic disease in parents and antibiotic use in infants, allergic disease in parents and exposure of infants to mold, and allergic disease in parents and moving an infant to a newly built house. The risk of current AR also increased in subjects with GA or AA at nucleotide 2044 in IL13 who had been exposed to mold in the home during infancy (adjusted odds ratio, 3.27; 95% CI, 1.75-6.11) compared with subjects who had GG at this position and had not been exposed to mold (adjusted odds ratio, 3.27; 95% CI, 1.75-6.11). CONCLUSION: The prevalence of AR is increasing in Korean children. Children with a family history of allergic disease and exposure to specific environmental risk factors during infancy are more likely to have AR. Children with GA or AA at IL13(+2044) are at increased risk for AR when exposed to mold in the home during the first year of life. Background The prevalence of allergic rhinitis (AR) is increasing worldwide. Allergic diseases develop in susceptible subjects when they are exposed to specific environmental factors. Objective We analyzed changes in the prevalence of AR and identified genetic and environmental factors in early childhood that affect risk. Methods We used the International Study of Asthma and Allergies in Childhood questionnaire to collect data on AR, allergies, and environmental exposures from 4554 elementary school students from 5 areas of Seoul, Korea, in 2008. We also obtained DNA from 1050 subjects from 1 area of Seoul for genotype analysis ofIL13. Results We identified genetic and environmental factors during infancy and early childhood that increased the risk for current AR (resulting in a diagnosis of AR and AR symptoms in the past 12 months) in elementary school-aged children. These included allergic disease in parents and antibiotic use in infants, allergic disease in parents and exposure of infants to mold, and allergic disease in parents and moving an infant to a newly built house. The risk of current AR also increased in subjects with GA or AA at nucleotide 2044 inIL13who had been exposed to mold in the home during infancy (adjusted odds ratio, 3.27; 95% CI, 1.75-6.11) compared with subjects who had GG at this position and had not been exposed to mold (adjusted odds ratio, 3.27; 95% CI, 1.75-6.11). Conclusion The prevalence of AR is increasing in Korean children. Children with a family history of allergic disease and exposure to specific environmental risk factors during infancy are more likely to have AR. Children with GA or AA atIL13(+2044)are at increased risk for AR when exposed to mold in the home during the first year of life. The prevalence of allergic rhinitis (AR) is increasing worldwide. Allergic diseases develop in susceptible subjects when they are exposed to specific environmental factors.BACKGROUNDThe prevalence of allergic rhinitis (AR) is increasing worldwide. Allergic diseases develop in susceptible subjects when they are exposed to specific environmental factors.We analyzed changes in the prevalence of AR and identified genetic and environmental factors in early childhood that affect risk.OBJECTIVEWe analyzed changes in the prevalence of AR and identified genetic and environmental factors in early childhood that affect risk.We used the International Study of Asthma and Allergies in Childhood questionnaire to collect data on AR, allergies, and environmental exposures from 4554 elementary school students from 5 areas of Seoul, Korea, in 2008. We also obtained DNA from 1050 subjects from 1 area of Seoul for genotype analysis of IL13.METHODSWe used the International Study of Asthma and Allergies in Childhood questionnaire to collect data on AR, allergies, and environmental exposures from 4554 elementary school students from 5 areas of Seoul, Korea, in 2008. We also obtained DNA from 1050 subjects from 1 area of Seoul for genotype analysis of IL13.We identified genetic and environmental factors during infancy and early childhood that increased the risk for current AR (resulting in a diagnosis of AR and AR symptoms in the past 12 months) in elementary school-aged children. These included allergic disease in parents and antibiotic use in infants, allergic disease in parents and exposure of infants to mold, and allergic disease in parents and moving an infant to a newly built house. The risk of current AR also increased in subjects with GA or AA at nucleotide 2044 in IL13 who had been exposed to mold in the home during infancy (adjusted odds ratio, 3.27; 95% CI, 1.75-6.11) compared with subjects who had GG at this position and had not been exposed to mold (adjusted odds ratio, 3.27; 95% CI, 1.75-6.11).RESULTSWe identified genetic and environmental factors during infancy and early childhood that increased the risk for current AR (resulting in a diagnosis of AR and AR symptoms in the past 12 months) in elementary school-aged children. These included allergic disease in parents and antibiotic use in infants, allergic disease in parents and exposure of infants to mold, and allergic disease in parents and moving an infant to a newly built house. The risk of current AR also increased in subjects with GA or AA at nucleotide 2044 in IL13 who had been exposed to mold in the home during infancy (adjusted odds ratio, 3.27; 95% CI, 1.75-6.11) compared with subjects who had GG at this position and had not been exposed to mold (adjusted odds ratio, 3.27; 95% CI, 1.75-6.11).The prevalence of AR is increasing in Korean children. Children with a family history of allergic disease and exposure to specific environmental risk factors during infancy are more likely to have AR. Children with GA or AA at IL13(+2044) are at increased risk for AR when exposed to mold in the home during the first year of life.CONCLUSIONThe prevalence of AR is increasing in Korean children. Children with a family history of allergic disease and exposure to specific environmental risk factors during infancy are more likely to have AR. Children with GA or AA at IL13(+2044) are at increased risk for AR when exposed to mold in the home during the first year of life. Background: The prevalence of allergic rhinitis (AR) is increasing worldwide. Allergic diseases develop in susceptible subjects when they are exposed to specific environmental factors. Objective: We analyzed changes in the prevalence of AR and identified genetic and environmental factors in early childhood that affect risk. Methods: We used the International Study of Asthma and Allergies in Childhood questionnaire to collect data on AR, allergies, and environmental exposures from 4554 elementary school students from 5 areas of Seoul, Korea, in 2008. We also obtained DNA from 1050 subjects from 1 area of Seoul for genotype analysis of IL13. Results: We identified genetic and environmental factors during infancy and early childhood that increased the risk for current AR (resulting in a diagnosis of AR and AR symptoms in the past 12 months) in elementary school-aged children. These included allergic disease in parents and antibiotic use in infants, allergic disease in parents and exposure of infants to mold, and allergic disease in parents and moving an infant to a newly built house. The risk of current AR also increased in subjects with GA or AA at nucleotide 2044 in IL13 who had been exposed to mold in the home during infancy (adjusted odds ratio, 3.27; 95% CI, 1.75-6.11) compared with subjects who had GG at this position and had not been exposed to mold (adjusted odds ratio, 3.27; 95% CI, 1.75-6.11). Conclusions: The prevalence of AR is increasing in Korean children. Children with a family history of allergic disease and exposure to specific environmental risk factors during infancy are more likely to have AR. Children with GA or AA at IL13(+2044) are at increased risk for AR when exposed to mold in the home during the first year of life. |
| Author | Kim, Woo Kyung Yu, Jinho Seo, Ju-Hee Kim, Hyo-Bin Kang, Mi-Jin Kim, Hyung Young Lee, So Yeon Kim, Byoung-Ju Kwon, Ji-Won Shin, Yee-Jin Kim, Kyung Won Hong, Soo-Jong |
| Author_xml | – sequence: 1 givenname: Woo Kyung surname: Kim fullname: Kim, Woo Kyung organization: Department of Pediatrics, Inje University Seoul Paik Hospital, Seoul, Korea – sequence: 2 givenname: Ji-Won surname: Kwon fullname: Kwon, Ji-Won organization: Department of Pediatrics, Seoul National University Bundang Hospital, Seoul, Korea – sequence: 3 givenname: Ju-Hee surname: Seo fullname: Seo, Ju-Hee organization: Department of Pediatrics, Childhood Asthma Atopy Center, Asan Medical Center, Research Center for Standardization of Allergic Diseases, University of Ulsan College of Medicine, Seoul, Korea – sequence: 4 givenname: Hyung Young surname: Kim fullname: Kim, Hyung Young organization: Department of Pediatrics, Childhood Asthma Atopy Center, Asan Medical Center, Research Center for Standardization of Allergic Diseases, University of Ulsan College of Medicine, Seoul, Korea – sequence: 5 givenname: Jinho surname: Yu fullname: Yu, Jinho organization: Department of Pediatrics, Childhood Asthma Atopy Center, Asan Medical Center, Research Center for Standardization of Allergic Diseases, University of Ulsan College of Medicine, Seoul, Korea – sequence: 6 givenname: Byoung-Ju surname: Kim fullname: Kim, Byoung-Ju organization: Department of Pediatrics, Inje University Haeundae Paik Hospital, Seoul, Korea – sequence: 7 givenname: Hyo-Bin surname: Kim fullname: Kim, Hyo-Bin organization: Department of Pediatrics, Inje University Sanggye Paik Hospital, Seoul, Korea – sequence: 8 givenname: So Yeon surname: Lee fullname: Lee, So Yeon organization: Department of Pediatrics, Hallym University Sacred Heart Hospital, Seoul, Korea – sequence: 9 givenname: Kyung Won surname: Kim fullname: Kim, Kyung Won organization: Department of Pediatrics, Severance Children's Hospital, College of Medicine, Yonsei University, Seoul, Korea – sequence: 10 givenname: Mi-Jin surname: Kang fullname: Kang, Mi-Jin organization: Asan Institute for Life Science, Seoul, Korea – sequence: 11 givenname: Yee-Jin surname: Shin fullname: Shin, Yee-Jin organization: Department of Psychiatry, Severance Hospital, College of Medicine, Yonsei University, Seoul, Korea – sequence: 12 givenname: Soo-Jong surname: Hong fullname: Hong, Soo-Jong email: sjhong@amc.seoul.kr organization: Department of Pediatrics, Childhood Asthma Atopy Center, Asan Medical Center, Research Center for Standardization of Allergic Diseases, University of Ulsan College of Medicine, Seoul, Korea |
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| Keywords | prevalence AR ISAAC IL-13 polymorphism OR SNP aOR Allergic rhinitis gene-environment interaction infancy risk factor Adjusted odd ratio International Study of Asthma and Allergies in Childhood Odds ratio Single nucleotide polymorphism Allergy Nose disease Prevalence Genetic variability Rhinitis Environmental factor Infant Risk Epidemiology Immunology Health and environment ENT disease Child Human Immunopathology Typing Cytokine Genotype Interleukin 13 Genotype environment interaction Risk factor Environment Polymorphism |
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| Snippet | The prevalence of allergic rhinitis (AR) is increasing worldwide. Allergic diseases develop in susceptible subjects when they are exposed to specific... Background The prevalence of allergic rhinitis (AR) is increasing worldwide. Allergic diseases develop in susceptible subjects when they are exposed to... Background: The prevalence of allergic rhinitis (AR) is increasing worldwide. Allergic diseases develop in susceptible subjects when they are exposed to... BACKGROUND: The prevalence of allergic rhinitis (AR) is increasing worldwide. Allergic diseases develop in susceptible subjects when they are exposed to... |
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| SubjectTerms | Age Allergens - immunology Allergic diseases Allergic rhinitis Allergies Allergy and Immunology Antibiotics Asthma Biological and medical sciences Child childhood Children Construction Materials - adverse effects Data processing Deoxyribonucleic acid Disease DNA elementary students Environment. Living conditions environmental exposure Environmental Exposure - adverse effects Environmental factors Families & family life Family medical history Female Fundamental and applied biological sciences. Psychology Fundamental immunology Fungi - immunology gene-environment interaction Genetic Predisposition to Disease Genetic testing Genetics genotype Genotype & phenotype Genotypes Houses Housing Humans Hypersensitivity IL-13 polymorphism Immunopathology infancy Infant Infants Interleukin 1 Interleukin 13 Interleukin-13 - genetics Interleukin-13 - immunology Inventories Korean Peninsula Koreans Logistics Male Medical sciences Molds Nucleotides Odds Ratio parents Parents & parenting Polymorphism Polymorphism, Genetic Prevalence Public health. Hygiene Public health. Hygiene-occupational medicine Questionnaires Republic of Korea - epidemiology Respiratory diseases Rhinitis Rhinitis, Allergic, Perennial - epidemiology Rhinitis, Allergic, Perennial - etiology Rhinitis, Allergic, Perennial - genetics Rhinitis, Allergic, Perennial - immunology risk factor Risk Factors Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis school children Smoke - adverse effects Students Studies Surveys and Questionnaires |
| Title | Interaction between IL13 genotype and environmental factors in the risk for allergic rhinitis in Korean children |
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