Molecular Profiling Reveals a Tumor-Promoting Phenotype of Monocytes and Macrophages in Human Cancer Progression

• Published in: Immunity (Cambridge, Mass.) Vol. 41; no. 5; pp. 815 - 829
• Main Authors: Chittezhath, Manesh, Dhillon, Manprit Kaur, Lim, Jyue Yuan, Laoui, Damya, Shalova, Irina N., Teo, Yi Ling, Chen, Jinmiao, Kamaraj, Revathy, Raman, Lata, Lum, Josephine, Thamboo, Thomas Paulraj, Chiong, Edmund, Zolezzi, Francesca, Yang, Henry, Van Ginderachter, Jo A., Poidinger, Michael, Wong, Alvin S.C., Biswas, Subhra K.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 20.11.2014; Elsevier Limited
• Subjects: Animals; Cancer; Cancer therapies; Carcinoma, Renal Cell - immunology; Cell Proliferation - genetics; Chemokines; Cytokines - biosynthesis; Cytokines - immunology; Gene expression; Gene Expression Profiling; Genotype & phenotype; Humans; Inflammation - immunology; Interleukin 1 Receptor Antagonist Protein - pharmacology; Interleukin-1beta - antagonists & inhibitors; Interleukin-1beta - biosynthesis; Interleukin-1beta - genetics; Interleukin-1beta - immunology; Kinases; Ligands; Macrophages - immunology; Medical prognosis; Medical research; Metastasis; Mice; Mice, Knockout; Mice, SCID; Monocytes - immunology; Myeloid Differentiation Factor 88; Neoplasm Transplantation; Neovascularization, Pathologic; Principal components analysis; Receptors, Interleukin-1 - antagonists & inhibitors; Receptors, Interleukin-1 - genetics; Receptors, Interleukin-1 - immunology; Transcription Factor RelA - genetics; Transplantation, Heterologous; Tumor Cells, Cultured

Monocytes and macrophages are major components of the tumor microenvironment, but their contributions to human cancer are poorly understood. We used molecular profiling combined with functional assays to investigate the role of these cells in human renal cell carcinoma (RCC). Blood monocytes from RC...