Establishment of an African green monkey model for COVID-19 and protection against re-infection

• Published in: Nature immunology Vol. 22; no. 1; pp. 86 - 98
• Main Authors: Woolsey, Courtney, Borisevich, Viktoriya, Prasad, Abhishek N., Agans, Krystle N., Deer, Daniel J., Dobias, Natalie S., Heymann, John C., Foster, Stephanie L., Levine, Corri B., Medina, Liana, Melody, Kevin, Geisbert, Joan B., Fenton, Karla A., Geisbert, Thomas W., Cross, Robert W.
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.01.2021; Nature Publishing Group
• Subjects: 631/326/596/4130; 692/420/254; Alveoli; Animal models; Animals; Antibodies, Viral - immunology; Biological markers; Biomedical and Life Sciences; Biomedicine; Bronchus; Chlorocebus aethiops; Coronaviridae; Coronaviruses; COVID-19; COVID-19 - epidemiology; COVID-19 - immunology; COVID-19 - virology; Disease Models, Animal; Epidemics; Epidemics - prevention & control; Gene expression; Gene Expression - genetics; Gene Expression - immunology; Gene Expression Profiling; Humans; Identification and classification; Immune clearance; Immune response; Immunology; Infectious Diseases; Interferon; Interferons - genetics; Interferons - immunology; Interferons - metabolism; Interleukin 6; Killer Cells, Natural - immunology; Killer Cells, Natural - metabolism; Laboratory animals; Lymphocytes T; Mucosa; Natural killer cells; Pandemics; Pathogenesis; Peripheral blood; Rectum; Reinfection - immunology; Reinfection - virology; Respiratory diseases; SARS-CoV-2 - immunology; SARS-CoV-2 - physiology; Severe acute respiratory syndrome coronavirus 2; T-Lymphocytes - immunology; T-Lymphocytes - metabolism; T-Lymphocytes - virology; United States

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for an unprecedented global pandemic of COVID-19. Animal models are urgently needed to study the pathogenesis of COVID-19 and to screen vaccines and treatments. We show that African green monkeys (AGMs) support robust SARS-C...