Plasma metabolome study reveals metabolic changes induced by pharmacological castration and testosterone supplementation in healthy young men

Testosterone is a hormone that plays a key role in carbohydrate, fat, and protein metabolism. Testosterone deficiency is associated with multiple comorbidities, e.g., metabolic syndrome and type 2 diabetes. Despite its importance in many metabolic pathways, the mechanisms by which it controls metabo...

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Published inScientific reports Vol. 12; no. 1; p. 15931
Main Authors de Siqueira Guedes, Jéssica, Pla, Indira, Sahlin, K. Barbara, Monnerat, Gustavo, Appelqvist, Roger, Marko-Varga, György, Giwercman, Aleksander, Domont, Gilberto Barbosa, Sanchez, Aniel, Nogueira, Fábio César Sousa, Malm, Johan
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 23.09.2022
Nature Publishing Group
Nature Portfolio
Subjects
631/45
692/163
Amino acids
Basic Medicine
Carbohydrate metabolism
Carnitine
Castration
Comorbidity
Diabetes mellitus (non-insulin dependent)
Fat metabolism
Follicle-stimulating hormone
Fysiologi
Humanities and Social Sciences
Indoles
Lipid metabolism
Lipids
Liquid chromatography
Luteinizing hormone
Mass spectrometry
Mass spectroscopy
Medical and Health Sciences
Medicin och hälsovetenskap
Medicinska och farmaceutiska grundvetenskaper
Metabolic disorders
Metabolic pathways
Metabolic syndrome
Metabolism
Metabolomics
multidisciplinary
Physiology
Plasma levels
Protein deficiency
Protein turnover
Science
Science (multidisciplinary)
Sphingolipids
Supplements
Testosterone
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Abstract Testosterone is a hormone that plays a key role in carbohydrate, fat, and protein metabolism. Testosterone deficiency is associated with multiple comorbidities, e.g., metabolic syndrome and type 2 diabetes. Despite its importance in many metabolic pathways, the mechanisms by which it controls metabolism are not fully understood. The present study investigated the short-term metabolic changes of pharmacologically induced castration and, subsequently, testosterone supplementation in healthy young males. Thirty subjects were submitted to testosterone depletion (TD) followed by testosterone supplementation (TS). Plasma samples were collected three times corresponding to basal, low, and restored testosterone levels. An untargeted metabolomics study was performed by liquid chromatography–high resolution mass spectrometry (UHPLC–HRMS) to monitor the metabolic changes induced by the altered hormone levels. Our results demonstrated that TD was associated with major metabolic changes partially restored by TS. Carnitine and amino acid metabolism were the metabolic pathways most impacted by variations in testosterone. Furthermore, our results also indicated that LH and FSH might strongly alter the plasma levels of indoles and lipids, especially glycerophospholipids and sphingolipids. Our results demonstrated major metabolic changes induced by low testosterone that may be important for understanding the mechanisms behind the association of testosterone deficiency and its comorbidities.
AbstractList Abstract Testosterone is a hormone that plays a key role in carbohydrate, fat, and protein metabolism. Testosterone deficiency is associated with multiple comorbidities, e.g., metabolic syndrome and type 2 diabetes. Despite its importance in many metabolic pathways, the mechanisms by which it controls metabolism are not fully understood. The present study investigated the short-term metabolic changes of pharmacologically induced castration and, subsequently, testosterone supplementation in healthy young males. Thirty subjects were submitted to testosterone depletion (TD) followed by testosterone supplementation (TS). Plasma samples were collected three times corresponding to basal, low, and restored testosterone levels. An untargeted metabolomics study was performed by liquid chromatography–high resolution mass spectrometry (UHPLC–HRMS) to monitor the metabolic changes induced by the altered hormone levels. Our results demonstrated that TD was associated with major metabolic changes partially restored by TS. Carnitine and amino acid metabolism were the metabolic pathways most impacted by variations in testosterone. Furthermore, our results also indicated that LH and FSH might strongly alter the plasma levels of indoles and lipids, especially glycerophospholipids and sphingolipids. Our results demonstrated major metabolic changes induced by low testosterone that may be important for understanding the mechanisms behind the association of testosterone deficiency and its comorbidities.
Testosterone is a hormone that plays a key role in carbohydrate, fat, and protein metabolism. Testosterone deficiency is associated with multiple comorbidities, e.g., metabolic syndrome and type 2 diabetes. Despite its importance in many metabolic pathways, the mechanisms by which it controls metabolism are not fully understood. The present study investigated the short-term metabolic changes of pharmacologically induced castration and, subsequently, testosterone supplementation in healthy young males. Thirty subjects were submitted to testosterone depletion (TD) followed by testosterone supplementation (TS). Plasma samples were collected three times corresponding to basal, low, and restored testosterone levels. An untargeted metabolomics study was performed by liquid chromatography–high resolution mass spectrometry (UHPLC–HRMS) to monitor the metabolic changes induced by the altered hormone levels. Our results demonstrated that TD was associated with major metabolic changes partially restored by TS. Carnitine and amino acid metabolism were the metabolic pathways most impacted by variations in testosterone. Furthermore, our results also indicated that LH and FSH might strongly alter the plasma levels of indoles and lipids, especially glycerophospholipids and sphingolipids. Our results demonstrated major metabolic changes induced by low testosterone that may be important for understanding the mechanisms behind the association of testosterone deficiency and its comorbidities.
Abstract Testosterone is a hormone that plays a key role in carbohydrate, fat, and protein metabolism. Testosterone deficiency is associated with multiple comorbidities, e.g., metabolic syndrome and type 2 diabetes. Despite its importance in many metabolic pathways, the mechanisms by which it controls metabolism are not fully understood. The present study investigated the short-term metabolic changes of pharmacologically induced castration and, subsequently, testosterone supplementation in healthy young males. Thirty subjects were submitted to testosterone depletion (TD) followed by testosterone supplementation (TS). Plasma samples were collected three times corresponding to basal, low, and restored testosterone levels. An untargeted metabolomics study was performed by liquid chromatography–high resolution mass spectrometry (UHPLC–HRMS) to monitor the metabolic changes induced by the altered hormone levels. Our results demonstrated that TD was associated with major metabolic changes partially restored by TS. Carnitine and amino acid metabolism were the metabolic pathways most impacted by variations in testosterone. Furthermore, our results also indicated that LH and FSH might strongly alter the plasma levels of indoles and lipids, especially glycerophospholipids and sphingolipids. Our results demonstrated major metabolic changes induced by low testosterone that may be important for understanding the mechanisms behind the association of testosterone deficiency and its comorbidities.
ArticleNumber 15931
Author de Siqueira Guedes, Jéssica
Appelqvist, Roger
Domont, Gilberto Barbosa
Nogueira, Fábio César Sousa
Sahlin, K. Barbara
Giwercman, Aleksander
Malm, Johan
Sanchez, Aniel
Pla, Indira
Monnerat, Gustavo
Marko-Varga, György
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  givenname: Indira
  surname: Pla
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  organization: Clinical Protein Science and Imaging, Department of Biomedical Engineering, Biomedical Centre, Lund University, Section for Clinical Chemistry, Department of Translational Medicine, Lund University, Skåne University Hospital Malmö
– sequence: 3
  givenname: K. Barbara
  surname: Sahlin
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  surname: Nogueira
  fullname: Nogueira, Fábio César Sousa
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  givenname: Johan
  surname: Malm
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Snippet Testosterone is a hormone that plays a key role in carbohydrate, fat, and protein metabolism. Testosterone deficiency is associated with multiple...
Abstract Testosterone is a hormone that plays a key role in carbohydrate, fat, and protein metabolism. Testosterone deficiency is associated with multiple...
Abstract Testosterone is a hormone that plays a key role in carbohydrate, fat, and protein metabolism. Testosterone deficiency is associated with multiple...
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SubjectTerms 631/45
692/163
Amino acids
Basic Medicine
Carbohydrate metabolism
Carnitine
Castration
Comorbidity
Diabetes mellitus (non-insulin dependent)
Fat metabolism
Follicle-stimulating hormone
Fysiologi
Humanities and Social Sciences
Indoles
Lipid metabolism
Lipids
Liquid chromatography
Luteinizing hormone
Mass spectrometry
Mass spectroscopy
Medical and Health Sciences
Medicin och hälsovetenskap
Medicinska och farmaceutiska grundvetenskaper
Metabolic disorders
Metabolic pathways
Metabolic syndrome
Metabolism
Metabolomics
multidisciplinary
Physiology
Plasma levels
Protein deficiency
Protein turnover
Science
Science (multidisciplinary)
Sphingolipids
Supplements
Testosterone
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Title Plasma metabolome study reveals metabolic changes induced by pharmacological castration and testosterone supplementation in healthy young men
URI https://link.springer.com/article/10.1038/s41598-022-19494-w
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https://pubmed.ncbi.nlm.nih.gov/PMC9508133
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https://doaj.org/article/2b36fc3ee4ae403e8d173aaa9d92941f
Volume 12
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