The DNA methylation landscape of human early embryos

• Published in: Nature (London) Vol. 511; no. 7511; pp. 606 - 610
• Main Authors: Guo, Hongshan, Zhu, Ping, Yan, Liying, Li, Rong, Hu, Boqiang, Lian, Ying, Yan, Jie, Ren, Xiulian, Lin, Shengli, Li, Junsheng, Jin, Xiaohu, Shi, Xiaodan, Liu, Ping, Wang, Xiaoye, Wang, Wei, Wei, Yuan, Li, Xianlong, Guo, Fan, Wu, Xinglong, Fan, Xiaoying, Yong, Jun, Wen, Lu, Xie, Sunney X., Tang, Fuchou, Qiao, Jie
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 31.07.2014; Nature Publishing Group
• Subjects: 631/136/2086; 631/136/2435; 631/337/176/1988; Analysis; Animals; Deoxyribonucleic acid; DNA; DNA Methylation; DNA Transposable Elements - genetics; Embryo, Mammalian; Embryonic development; Embryonic growth stage; Embryonic Stem Cells - physiology; Embryos; Epigenesis, Genetic; Epigenetic inheritance; Female; Gene Expression Profiling; Gene Expression Regulation, Developmental; Genes; Genome-wide association studies; Genomes; Genomics; Germ Cells - metabolism; Histones - metabolism; Humanities and Social Sciences; Humans; letter; Long Interspersed Nucleotide Elements - genetics; Male; Methylation; Mice; multidisciplinary; Promoter Regions, Genetic - genetics; Science; Short Interspersed Nucleotide Elements - genetics; Stem cells

Base-resolution maps of DNA methylation in human gametes and early embryos offer novel insights into human methylation dynamics and the functional relationship between DNA methylation and gene expression. DNA methylation in the early embryo Global patterns of DNA methylation are drastically reprogra...