Nematocida displodere mechanosensitive ion channel of small conductance 2 assembles into a unique 6-channel super-structure in vitro

• Published in: PloS one Vol. 19; no. 7; p. e0301951
• Main Authors: Berg, Alexandra, Berntsson, Ronnie P-A, Barandun, Jonas
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 22.07.2024; Public Library of Science (PLoS)
• Subjects: Animals; Biology and Life Sciences; Caenorhabditis elegans - genetics; Caenorhabditis elegans - metabolism; Conductance; Cryoelectron Microscopy; E coli; Electron microscopy; Gene duplication; Gene transfer; Genes; Genomes; Genomics; Horizontal transfer; Intracellular; Ion channels; Ion Channels - chemistry; Ion Channels - genetics; Ion Channels - metabolism; Ion flux; Ions; Mechanotransduction, Cellular; Medicine and Health Sciences; Membrane proteins; Membranes; Microsporidia; Microsporidia - genetics; Microsporidia - metabolism; Pathogens; Physical Sciences; Proteins; Research and Analysis Methods; Superstructures

Mechanosensitive ion channels play an essential role in reacting to environmental signals and sustaining cell integrity by facilitating ion flux across membranes. For obligate intracellular pathogens like microsporidia, adapting to changes in the host environment is crucial for survival and propagat...