Pharmacogenetic approaches to the treatment of alcohol addiction

• Published in: Nature reviews. Neuroscience Vol. 12; no. 11; pp. 670 - 684
• Main Authors: Heilig, Markus, Goldman, David, Berrettini, Wade, O'Brien, Charles P.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.11.2011; Nature Publishing Group
• Subjects: 692/700/565/1436/434; ACTH; Addiction; Addictions; Alcohol use; Alcoholism; Alcoholism - drug therapy; Alcoholism - genetics; Analgesics, Opioid - therapeutic use; Animal Genetics and Genomics; Behavioral Sciences; Biological Techniques; Biomedical and Life Sciences; Biomedicine; Care and treatment; Chronic illnesses; Clinical outcomes; Drug therapy; GABA; Genetic aspects; Health aspects; Health risk assessment; Humans; Narcotics; Neurobiology; Neurosciences; Pharmacogenetics; Physiological aspects; Polymorphism, Single Nucleotide; Receptors, Opioid - genetics; review-article; Risk factors; United States; United States > US; Maryland

Key Points Addictive disorders are common, account for a tremendous disease burden and are in need of improved medical treatments. Alcohol use accounts for more disease burden than any other addictive drug with the exception of nicotine. The discovery of naltrexone as a medication for alcoholism was...