Regulation of cell proliferation and malignant potential by irisin in endometrial, colon, thyroid and esophageal cancer cell lines

• Published in: Metabolism, clinical and experimental Vol. 63; no. 2; pp. 188 - 193
• Main Authors: Moon, Hyun-Seuk, Mantzoros, Christos S
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.02.2014; Elsevier
• Subjects: Animals; Biological and medical sciences; Cell Line, Tumor; Cell proliferation; Cell Proliferation - drug effects; Colonic Neoplasms - pathology; Colonic Neoplasms - physiopathology; Endocrinology & Metabolism; Endometrial Neoplasms - pathology; Endometrial Neoplasms - physiopathology; Esophageal Neoplasms - pathology; Esophageal Neoplasms - physiopathology; Feeding. Feeding behavior; Female; Female genital diseases; Fibronectins - metabolism; Fibronectins - pharmacology; Fundamental and applied biological sciences. Psychology; Gynecology. Andrology. Obstetrics; Humans; Irisin; Malignant potential; Medical sciences; Mice; Multiple tumors. Solid tumors. Tumors in childhood (general aspects); Neoplastic Stem Cells; Obesity-related cancer; Thyroid Neoplasms - pathology; Thyroid Neoplasms - physiopathology; Tumors; Vertebrates: anatomy and physiology, studies on body, several organs or systems; FNDC5; Cell proliferation; Irisin; Obesity-related cancer; PGC1α; Otsuka Long–Evans Tokushima Fatty rats; OLETF; LETO; Malignant potential; fibronectin type III domain containing 5; Long Evans Tokushima Otsuka rats; proliferator-activated receptor gamma co-activator 1-α; Endocrinopathy; Endometrium cancer; Esophageal disease; Thyroid diseases; Malignant tumor; Esophagus cancer; Female genital diseases; Colonic disease; Regulation(control); Thyroid cancer; Colon cancer; Cell line; Uterine diseases; Digestive diseases; Intestinal disease; Tumor cell; Endocrinology; Cancer

Abstract Objective Irisin is a novel hormone that has been proposed to mediate the beneficial effects of exercise on metabolism, including body weight regulation and insulin resistance. No previous studies have evaluated whether irisin may regulate cell proliferation and malignant potential of obesi...