DNA-Methyltransferase 1 mRNA Is Selectively Overexpressed in Telencephalic GABAergic Interneurons of Schizophrenia Brains

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 101; no. 1; pp. 348 - 353
• Main Authors: Veldic, M., Caruncho, H. J., Liu, W. S., Davis, J., Satta, R., Grayson, D. R., Guidotti, A., Costa, E.
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 06.01.2004; National Acad Sciences
• Subjects: Adult; Aged; Antipsychotic agents; Biological Sciences; Brain; Case-Control Studies; Cell Adhesion Molecules, Neuronal - genetics; Cell Adhesion Molecules, Neuronal - metabolism; Chromatin; Deoxyribonucleic acid; DNA; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases - genetics; DNA (Cytosine-5-)-Methyltransferases - metabolism; DNA Methylation; Down regulation; Enzymes; Extracellular Matrix Proteins - genetics; Extracellular Matrix Proteins - metabolism; Female; gamma-Aminobutyric Acid - metabolism; Gene Expression; Glutamate Decarboxylase - genetics; Glutamate Decarboxylase - metabolism; Humans; In situ hybridization; Interneurons; Interneurons - enzymology; Isoenzymes - genetics; Isoenzymes - metabolism; Male; Mental disorders; Messenger RNA; Methylation; Middle Aged; Nerve Tissue Proteins; Neurons; Promoter Regions, Genetic; Purkinje cells; reelin; Ribonucleic acid; RNA; RNA, Messenger - genetics; RNA, Messenger - metabolism; Schizophrenia; Schizophrenia - enzymology; Schizophrenia - genetics; Serine Endopeptidases; Telencephalon - enzymology
• ISSN: 0027-8424; 1091-6490
• DOI: 10.1073/pnas.2637013100

A down-regulation of reelin and glutamic acid decarboxylase (GAD) 67 mRNAs was detected in γ-aminobutyric acid (GABA)ergic cortical interneurons of schizophrenia (SZ) postmortem brains (10), suggesting that the availability of GABA and reelin may be decreased in SZ cortex. In situ hybridization of t...