Molecular mechanisms of mitochondrial DNA release and activation of the cGAS-STING pathway

• Published in: Experimental & molecular medicine Vol. 55; no. 3; pp. 510 - 519
• Main Authors: Kim, Jeonghan, Kim, Ho-Shik, Chung, Jay H.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.03.2023; Springer Nature B.V; Nature Publishing Group; 생화학분자생물학회
• Subjects: Amyotrophic lateral sclerosis; Antiviral drugs; Biomedical and Life Sciences; Biomedicine; Chromatin; DNA viruses; DNA, Mitochondrial - genetics; DNA, Mitochondrial - metabolism; Humans; Immune response; Immunity, Innate; Inflammasomes; Inflammasomes - metabolism; Inflammation; Inflammation - metabolism; Inflammatory diseases; Innate immunity; Localization; Macrophages; Medical Biochemistry; Membrane Proteins - metabolism; Mitochondria; Mitochondria - metabolism; Mitochondrial DNA; Molecular Medicine; Molecular modelling; Neurodegenerative diseases; Nucleotidyltransferases - genetics; Oligomerization; Pathogens; Review Article; Signal Transduction; Stem Cells; 생화학

In addition to constituting the genetic material of an organism, DNA is a tracer for the recognition of foreign pathogens and a trigger of the innate immune system. cGAS functions as a sensor of double-stranded DNA fragments and initiates an immune response via the adaptor protein STING. The cGAS-ST...