Rate and Molecular Spectrum of Spontaneous Mutations in Arabidopsis thaliana
To take complete advantage of information on within-species polymorphism and divergence from close relatives, one needs to know the rate and the molecular spectrum of spontaneous mutations. To this end, we have searched for de novo spontaneous mutations in the complete nuclear genomes of five Arabid...
Saved in:
| Published in | Science (American Association for the Advancement of Science) Vol. 327; no. 5961; pp. 92 - 94 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Washington, DC
American Association for the Advancement of Science
2010
The American Association for the Advancement of Science |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0036-8075 1095-9203 1095-9203 |
| DOI | 10.1126/science.1180677 |
Cover
Loading…
| Abstract | To take complete advantage of information on within-species polymorphism and divergence from close relatives, one needs to know the rate and the molecular spectrum of spontaneous mutations. To this end, we have searched for de novo spontaneous mutations in the complete nuclear genomes of five Arabidopsis thaliana mutation accumulation lines that had been maintained by single-seed descent for 30 generations. We identified and validated 99 base substitutions and 17 small and large insertions and deletions. Our results imply a spontaneous mutation rate of 7 x 10⁻⁹ base substitutions per site per generation, the majority of which are G:C[rightward arrow]A:T transitions. We explain this very biased spectrum of base substitution mutations as a result of two main processes: deamination of methylated cytosines and ultraviolet light-induced mutagenesis. |
|---|---|
| AbstractList | To take complete advantage of information on within-species polymorphism and divergence from close relatives, one needs to know the rate and the molecular spectrum of spontaneous mutations. To this end, we have searched for de novo spontaneous mutations in the complete nuclear genomes of five Arabidopsis thaliana mutation accumulation lines that had been maintained by single-seed descent for 30 generations. We identified and validated 99 base substitutions and 17 small and large insertions and deletions. Our results imply a spontaneous mutation rate of 7 x 10⁻⁹ base substitutions per site per generation, the majority of which are G:C[rightward arrow]A:T transitions. We explain this very biased spectrum of base substitution mutations as a result of two main processes: deamination of methylated cytosines and ultraviolet light-induced mutagenesis. To take complete advantage of information on within-species polymorphism and divergence from close relatives, one needs to know the rate and the molecular spectrum of spontaneous mutations. To this end, we have searched for de novo spontaneous mutations in the complete nuclear genomes of five Arabidopsis thaliana mutation accumulation lines that had been maintained by single-seed descent for 30 generations. We identified and validated 99 base substitutions and 17 small and large insertions and deletions. Our results imply a spontaneous mutation rate of 7 × 10 −9 base substitutions per site per generation, the majority of which are G:C→A:T transitions. We explain this very biased spectrum of base substitution mutations as a result of two main processes: deamination of methylated cytosines and ultraviolet light–induced mutagenesis. Rates of evolution in gene and genome sequences have been estimated, but these estimates are subject to error because many of the steps of evolution over the ages are not directly measurable or are hidden under subsequent changes. Ossowski et al. (p. 92 ) now provide a more accurate measurement of how often spontaneous mutations arise in a nuclear genome. Mutations arising over 30 generations were compared by sequencing DNA from individual Arabidopsis thaliana plants. UV- and deamination-induced mutagenesis appeared to bias the type of mutations found. Rapid sequencing technologies allow a more accurate calculation of the mutation rate for plants. To take complete advantage of information on within-species polymorphism and divergence from close relatives, one needs to know the rate and the molecular spectrum of spontaneous mutations. To this end, we have searched for de novo spontaneous mutations in the complete nuclear genomes of five Arabidopsis thaliana mutation accumulation lines that had been maintained by single-seed descent for 30 generations. We identified and validated 99 base substitutions and 17 small and large insertions and deletions. Our results imply a spontaneous mutation rate of 7 × 10 −9 base substitutions per site per generation, the majority of which are G:C→A:T transitions. We explain this very biased spectrum of base substitution mutations as a result of two main processes: deamination of methylated cytosines and ultraviolet light–induced mutagenesis. To take complete advantage of information on within-species polymorphism and divergence from close relatives, one needs to know the rate and the molecular spectrum of spontaneous mutations. To this end, we have searched for de novo spontaneous mutations in the complete nuclear genomes of five Arabidopsis thaliana mutation accumulation lines that had been maintained by single-seed descent for 30 generations. We identified and validated 99 base substitutions and 17 small and large insertions and deletions. Our results imply a spontaneous mutation rate of 7 x 10(-9) base substitutions per site per generation, the majority of which are G:C-->A:T transitions. We explain this very biased spectrum of base substitution mutations as a result of two main processes: deamination of methylated cytosines and ultraviolet light-induced mutagenesis. To take complete advantage of information on within-species polymorphism and divergence from close relatives, one needs to know the rate and the molecular spectrum of spontaneous mutations. To this end, we have searched for de novo spontaneous mutations in the complete nuclear genomes of five Arabidopsis thaliana mutation accumulation lines that had been maintained by single-seed descent for 30 generations. We identified and validated 99 base substitutions and 17 small and large insertions and deletions. Our results imply a spontaneous mutation rate of 7 x 10(-9) base substitutions per site per generation, the majority of which are G:C-->A:T transitions. We explain this very biased spectrum of base substitution mutations as a result of two main processes: deamination of methylated cytosines and ultraviolet light-induced mutagenesis.To take complete advantage of information on within-species polymorphism and divergence from close relatives, one needs to know the rate and the molecular spectrum of spontaneous mutations. To this end, we have searched for de novo spontaneous mutations in the complete nuclear genomes of five Arabidopsis thaliana mutation accumulation lines that had been maintained by single-seed descent for 30 generations. We identified and validated 99 base substitutions and 17 small and large insertions and deletions. Our results imply a spontaneous mutation rate of 7 x 10(-9) base substitutions per site per generation, the majority of which are G:C-->A:T transitions. We explain this very biased spectrum of base substitution mutations as a result of two main processes: deamination of methylated cytosines and ultraviolet light-induced mutagenesis. To take complete advantage of information on within-species polymorphism and divergence from close relatives, one needs to know the rate and the molecular spectrum of spontaneous mutations. To this end, we have searched for de novo spontaneous mutations in the complete nuclear genomes of five Arabidopsis thaliana mutation accumulation lines that had been maintained by single-seed descent for 30 generations. We identified and validated 99 base substitutions and 17 small and large insertions and deletions. Our results imply a spontaneous mutation rate of 7 × 10-9 base substitutions per site per generation, the majority of which are G:C[arrow right]A:T transitions. We explain this very biased spectrum of base substitution mutations as a result of two main processes: deamination of methylated cytosines and ultraviolet light-induced mutagenesis. [PUBLICATION ABSTRACT] To take complete advantage of information on within-species polymorphism and divergence from close relatives, one needs to know the rate and the molecular spectrum of spontaneous mutations. To this end, we have searched for de novo spontaneous mutations in the complete nuclear genomes of five Arabidopsis thaliana mutation accumulation lines that had been maintained by single-seed descent for 30 generations. We identified and validated 99 base substitutions and 17 small and large insertions and deletions. Our results imply a spontaneous mutation rate of 7 x 10⁻⁹ base substitutions per site per generation, the majority of which are G: C-» A: T transitions. We explain this very biased spectrum of base substitution mutations as a result of two main processes: deamination of methylated cytosines and ultraviolet light-induced mutagenesis. |
| Author | Lucas-Lledó, José Ignacio Schneeberger, Korbinian Weigel, Detlef Lynch, Michael Ossowski, Stephan Shaw, Ruth G Warthmann, Norman Clark, Richard M |
| AuthorAffiliation | 3 Department of Biology, University of Utah, Salt Lake City, UT 84112, USA 4 Department of Ecology, Evolution, and Behavior, University of Minnesota, St. Paul, MN 55108, USA 1 Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tübingen, Germany 2 Department of Biology, Indiana University, Bloomington, IN 47405, USA |
| AuthorAffiliation_xml | – name: 1 Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tübingen, Germany – name: 2 Department of Biology, Indiana University, Bloomington, IN 47405, USA – name: 3 Department of Biology, University of Utah, Salt Lake City, UT 84112, USA – name: 4 Department of Ecology, Evolution, and Behavior, University of Minnesota, St. Paul, MN 55108, USA |
| Author_xml | – sequence: 1 fullname: Ossowski, Stephan – sequence: 2 fullname: Schneeberger, Korbinian – sequence: 3 fullname: Lucas-Lledó, José Ignacio – sequence: 4 fullname: Warthmann, Norman – sequence: 5 fullname: Clark, Richard M – sequence: 6 fullname: Shaw, Ruth G – sequence: 7 fullname: Weigel, Detlef – sequence: 8 fullname: Lynch, Michael |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22280699$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/20044577$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFkstv1DAQxiNURLeFMycgQgJOS8dv54JUVbykrZAoPVsTx2m9ytqLnSDx3-NVlgV6KCfbmt83D893Uh2FGFxVPSXwlhAqz7L1LlhXHhqkUg-qBYFGLBsK7KhaADC51KDEcXWS8xqgxBr2qDqmAJwLpRbV6iuOrsbQ1ZdxcHYaMNVXW2fHNG3q2Jd7DCMGF6dcX04jjj6GXPtQnydsfRe32ed6vMXBY8DH1cMeh-ye7M_T6vrD-28Xn5arLx8_X5yvllZoOS7R9ZT1QjhtW8mIVhJRtgA9d7p3SKHRCnf99cSxVjqNFoGJtuNUdZ0Ddlq9m_Nup3bjOuvCmHAw2-Q3mH6aiN78Gwn-1tzEH4ZppbUUJcGbfYIUv08uj2bjs3XDME9qFOOUNISRQr6-l-SSC625_C_IJKdSS1XAl3fAdZxSKP9lKGESBOW7ss__nvAw2u_FFeDVHsBscegTBuvzH47SYoimKdzZzNkUc06uPyAEzM5CZm8hs7dQUYg7CuvnvZev9MM9umezbp3HmA5lOAjQDHZLezHHe4wGb1Lp9vqKAmFAFAXRcPYLbhzfWQ |
| CODEN | SCIEAS |
| CitedBy_id | crossref_primary_10_1186_s12915_023_01745_5 crossref_primary_10_1186_s12870_023_04315_7 crossref_primary_10_1093_molbev_msac169 crossref_primary_10_1534_genetics_119_302054 crossref_primary_10_1038_s41467_018_06932_5 crossref_primary_10_1186_s13068_024_02562_w crossref_primary_10_1111_mec_13738 crossref_primary_10_1111_tpj_15557 crossref_primary_10_1534_genetics_111_134668 crossref_primary_10_1016_j_cub_2016_03_067 crossref_primary_10_1098_rstb_2012_0083 crossref_primary_10_1007_s11248_016_9981_1 crossref_primary_10_1016_j_dnarep_2024_103801 crossref_primary_10_1534_genetics_113_158196 crossref_primary_10_1101_gr_152538_112 crossref_primary_10_1111_tpj_13132 crossref_primary_10_1371_journal_pone_0074479 crossref_primary_10_1038_emboj_2010_313 crossref_primary_10_1111_j_1365_294X_2012_05460_x crossref_primary_10_1093_dnares_dsad012 crossref_primary_10_1093_aob_mcab128 crossref_primary_10_1111_nph_17456 crossref_primary_10_1111_nph_17699 crossref_primary_10_1104_pp_110_169748 crossref_primary_10_1093_aob_mcu017 crossref_primary_10_1186_s12896_016_0271_z crossref_primary_10_1007_s00253_019_09626_0 crossref_primary_10_1016_j_pmpp_2023_101968 crossref_primary_10_1111_mec_13721 crossref_primary_10_1139_cjps_2017_0364 crossref_primary_10_1093_molbev_mss024 crossref_primary_10_1371_journal_pgen_1007949 crossref_primary_10_1093_sysbio_sys048 crossref_primary_10_1016_j_molp_2018_04_009 crossref_primary_10_1002_ece3_4533 crossref_primary_10_3390_plants8120570 crossref_primary_10_1016_j_pld_2023_07_004 crossref_primary_10_1016_j_pbi_2020_101989 crossref_primary_10_1093_genetics_iyad128 crossref_primary_10_1146_annurev_genet_120215_035254 crossref_primary_10_1093_molbev_mss249 crossref_primary_10_1016_j_algal_2024_103694 crossref_primary_10_1111_mec_13705 crossref_primary_10_1371_journal_pbio_1002419 crossref_primary_10_1371_journal_pgen_1004410 crossref_primary_10_1186_s12870_024_05628_x crossref_primary_10_1534_genetics_118_300848 crossref_primary_10_1186_s12862_020_01661_0 crossref_primary_10_1186_s13104_020_4883_y crossref_primary_10_1007_s11103_015_0293_2 crossref_primary_10_1105_tpc_110_073999 crossref_primary_10_1126_sciadv_abm9385 crossref_primary_10_1079_PAVSNNR202116047 crossref_primary_10_1093_molbev_msad031 crossref_primary_10_1016_j_pbi_2020_101990 crossref_primary_10_1534_genetics_118_301721 crossref_primary_10_1002_em_20613 crossref_primary_10_1093_gbe_evz130 crossref_primary_10_1002_ece3_5888 crossref_primary_10_1038_ncomms5104 crossref_primary_10_1038_s41467_017_02063_5 crossref_primary_10_2903_j_efsa_2012_2943 crossref_primary_10_1111_tpj_14427 crossref_primary_10_3389_fpls_2022_838536 crossref_primary_10_3390_cells10051224 crossref_primary_10_1093_molbev_msae135 crossref_primary_10_1101_gr_178335_114 crossref_primary_10_1186_s12870_018_1474_3 crossref_primary_10_1016_j_semcdb_2019_06_005 crossref_primary_10_1104_pp_111_185074 crossref_primary_10_1134_S002689332206019X crossref_primary_10_1002_1873_3468_12248 crossref_primary_10_3389_fpls_2021_681801 crossref_primary_10_3390_agronomy12091990 crossref_primary_10_1038_s41467_022_34795_4 crossref_primary_10_1007_s10265_018_1064_3 crossref_primary_10_1111_bij_12116 crossref_primary_10_1073_pnas_1903809116 crossref_primary_10_1007_s13353_011_0058_9 crossref_primary_10_1016_j_ijbiomac_2024_134051 crossref_primary_10_1111_evo_13892 crossref_primary_10_1105_tpc_114_124297 crossref_primary_10_1371_journal_pone_0222283 crossref_primary_10_1534_g3_120_401704 crossref_primary_10_1146_annurev_ecolsys_110218_024955 crossref_primary_10_1093_gbe_evy252 crossref_primary_10_1007_s42977_022_00146_z crossref_primary_10_1007_s00606_017_1411_1 crossref_primary_10_1111_mec_14426 crossref_primary_10_1111_mec_16849 crossref_primary_10_1186_s12864_024_10405_z crossref_primary_10_1371_journal_pgen_1003754 crossref_primary_10_1111_j_1365_313X_2010_04284_x crossref_primary_10_1093_gbe_evu284 crossref_primary_10_1093_aob_mcx112 crossref_primary_10_1093_gbe_evw223 crossref_primary_10_1371_journal_pone_0033541 crossref_primary_10_1007_s00122_023_04262_9 crossref_primary_10_3389_fevo_2024_1335452 crossref_primary_10_3390_d9040045 crossref_primary_10_1007_s11627_021_10182_4 crossref_primary_10_1111_j_1365_294X_2010_04835_x crossref_primary_10_1371_journal_pone_0183412 crossref_primary_10_1371_journal_pgen_1002652 crossref_primary_10_1111_jbi_12876 crossref_primary_10_1038_s41467_018_05281_7 crossref_primary_10_1093_gbe_evu271 crossref_primary_10_1371_journal_pone_0131508 crossref_primary_10_1038_s41586_021_04269_6 crossref_primary_10_1007_s11240_019_01589_4 crossref_primary_10_1111_bij_12342 crossref_primary_10_1073_pnas_1211021109 crossref_primary_10_1371_journal_pcbi_1008296 crossref_primary_10_1038_nrg_2016_45 crossref_primary_10_1111_j_1365_294X_2011_05434_x crossref_primary_10_1111_nph_19227 crossref_primary_10_1038_nrg3564 crossref_primary_10_1111_1755_0998_13104 crossref_primary_10_1016_j_tplants_2024_09_008 crossref_primary_10_1007_s10722_015_0242_6 crossref_primary_10_1111_tpj_13511 crossref_primary_10_3390_ijms21072590 crossref_primary_10_1186_s13059_020_02131_y crossref_primary_10_1038_s41580_024_00769_1 crossref_primary_10_1093_jxb_erw333 crossref_primary_10_1073_pnas_2208575119 crossref_primary_10_1038_s41598_022_19928_5 crossref_primary_10_1007_s11248_015_9867_7 crossref_primary_10_1073_pnas_1616736114 crossref_primary_10_1111_tpj_13524 crossref_primary_10_3389_fpls_2021_730258 crossref_primary_10_3835_plantgenome2016_05_0047 crossref_primary_10_1093_pnasnexus_pgae094 crossref_primary_10_3389_fgene_2019_00487 crossref_primary_10_1016_j_tplants_2019_08_007 crossref_primary_10_3389_fgene_2020_542017 crossref_primary_10_1016_j_cub_2018_03_020 crossref_primary_10_1111_pce_13811 crossref_primary_10_1038_s41598_017_14628_x crossref_primary_10_1098_rsfs_2019_0120 crossref_primary_10_1016_j_tim_2013_09_003 crossref_primary_10_1146_annurev_genet_120213_092110 crossref_primary_10_1093_genetics_iyad146 crossref_primary_10_1093_molbev_msx064 crossref_primary_10_1007_s12042_016_9165_4 crossref_primary_10_1016_j_cub_2018_04_069 crossref_primary_10_1093_jhered_esae058 crossref_primary_10_1186_s13059_021_02348_5 crossref_primary_10_1038_nature11968 crossref_primary_10_1186_s12864_017_4394_y crossref_primary_10_3390_genes10110894 crossref_primary_10_1093_biolinnean_blx071 crossref_primary_10_3390_genes12091391 crossref_primary_10_1186_s13059_017_1378_9 crossref_primary_10_1016_j_gde_2013_10_006 crossref_primary_10_1111_jeb_14162 crossref_primary_10_1111_tpj_13738 crossref_primary_10_1101_gr_251207_119 crossref_primary_10_1093_molbev_msz259 crossref_primary_10_3390_jmse10020168 crossref_primary_10_1038_s41477_023_01367_3 crossref_primary_10_1093_jhered_esae046 crossref_primary_10_1073_pnas_1109273108 crossref_primary_10_1111_jbi_13918 crossref_primary_10_1111_mec_15936 crossref_primary_10_1371_journal_pgen_1001115 crossref_primary_10_1371_journal_pone_0161355 crossref_primary_10_1093_nar_gkw1259 crossref_primary_10_1073_pnas_1424254112 crossref_primary_10_1016_j_tig_2024_11_002 crossref_primary_10_1002_ece3_2558 crossref_primary_10_1371_journal_pone_0282932 crossref_primary_10_1016_j_ydbio_2016_07_003 crossref_primary_10_1111_tpj_12860 crossref_primary_10_7554_eLife_14625 crossref_primary_10_1093_dnares_dsv027 crossref_primary_10_3390_ijms21030707 crossref_primary_10_1016_j_xplc_2022_100413 crossref_primary_10_1534_genetics_119_302045 crossref_primary_10_1002_bies_201500058 crossref_primary_10_1371_journal_pgen_1001104 crossref_primary_10_1007_s10265_015_0709_8 crossref_primary_10_1101_gr_231753_117 crossref_primary_10_1111_plb_12375 crossref_primary_10_1371_journal_pone_0048862 crossref_primary_10_1093_g3journal_jkac150 crossref_primary_10_1111_nph_12863 crossref_primary_10_1371_journal_pgen_1011141 crossref_primary_10_7554_eLife_89470 crossref_primary_10_1016_j_xplc_2022_100420 crossref_primary_10_1534_genetics_116_199190 crossref_primary_10_1186_s13059_020_02162_5 crossref_primary_10_1016_j_scitotenv_2024_171567 crossref_primary_10_1093_jxb_erw066 crossref_primary_10_1534_genetics_113_158758 crossref_primary_10_1101_gr_177659_114 crossref_primary_10_1073_pnas_1018222108 crossref_primary_10_1093_bioinformatics_bty165 crossref_primary_10_3390_epigenomes6040031 crossref_primary_10_1093_molbev_msz206 crossref_primary_10_1371_journal_pgen_1007155 crossref_primary_10_2135_cropsci2015_04_0220 crossref_primary_10_1093_gbe_evs027 crossref_primary_10_1093_gbe_evs028 crossref_primary_10_1371_journal_pbio_3002191 crossref_primary_10_1007_s10682_022_10205_5 crossref_primary_10_1534_g3_113_007815 crossref_primary_10_1073_pnas_1323011111 crossref_primary_10_1101_gr_219303_116 crossref_primary_10_1016_j_tig_2010_05_003 crossref_primary_10_1016_j_gpb_2018_07_009 crossref_primary_10_1126_science_adh9443 crossref_primary_10_1007_s00299_016_1993_z crossref_primary_10_3389_fpls_2017_00402 crossref_primary_10_1111_1755_0998_13897 crossref_primary_10_1093_gbe_evq081 crossref_primary_10_1038_s41467_018_06108_1 crossref_primary_10_1186_s12864_018_4753_3 crossref_primary_10_1038_s41467_018_04256_y crossref_primary_10_1016_j_pbi_2016_01_003 crossref_primary_10_1007_s12284_010_9046_7 crossref_primary_10_3390_ijms232112860 crossref_primary_10_1073_pnas_1609686113 crossref_primary_10_3390_plants10010144 crossref_primary_10_1007_s00438_013_0783_3 crossref_primary_10_3389_fevo_2021_681100 crossref_primary_10_1534_genetics_113_159863 crossref_primary_10_1093_gbe_evac043 crossref_primary_10_1186_s12864_015_1285_y crossref_primary_10_1007_s00438_019_01614_3 crossref_primary_10_1093_evolut_qpac010 crossref_primary_10_1371_journal_pone_0186663 crossref_primary_10_1016_j_tig_2021_04_010 crossref_primary_10_1093_eep_dvx002 crossref_primary_10_1111_mec_15448 crossref_primary_10_1111_ddi_13288 crossref_primary_10_1146_annurev_phyto_080615_100308 crossref_primary_10_1038_s41438_021_00612_0 crossref_primary_10_1007_s11738_017_2600_9 crossref_primary_10_1016_j_mimet_2013_09_010 crossref_primary_10_1093_gbe_evac059 crossref_primary_10_1111_jeb_13535 crossref_primary_10_1371_journal_pgen_1008698 crossref_primary_10_7554_eLife_89470_4 crossref_primary_10_1016_j_ympev_2017_05_026 crossref_primary_10_1038_ng_911 crossref_primary_10_1093_gigascience_giac106 crossref_primary_10_1126_science_1212959 crossref_primary_10_1371_journal_pone_0242624 crossref_primary_10_1007_s12042_014_9135_7 crossref_primary_10_1534_genetics_111_128744 crossref_primary_10_1111_mec_14107 crossref_primary_10_1134_S0026893320010069 crossref_primary_10_1534_g3_115_023671 crossref_primary_10_1038_s41438_020_0284_6 crossref_primary_10_1371_journal_pgen_1004920 crossref_primary_10_1111_j_1365_2699_2012_02775_x crossref_primary_10_1111_mec_16764 crossref_primary_10_3389_fpls_2023_1212967 crossref_primary_10_1186_1759_8753_3_2 crossref_primary_10_1270_jsbbs_22100 crossref_primary_10_1093_pcp_pcr029 crossref_primary_10_1111_jse_12543 crossref_primary_10_3390_plants12091734 crossref_primary_10_1093_gbe_evac038 crossref_primary_10_1093_gbe_evae213 crossref_primary_10_1093_molbev_msw141 crossref_primary_10_3390_genes12050719 crossref_primary_10_21273_HORTSCI16001_21 crossref_primary_10_1093_molbev_msv055 crossref_primary_10_1016_j_plantsci_2010_07_019 crossref_primary_10_1080_17550874_2017_1393702 crossref_primary_10_1007_s11816_019_00562_z crossref_primary_10_1111_mec_14325 crossref_primary_10_1534_g3_120_401269 crossref_primary_10_1038_s41477_024_01807_8 crossref_primary_10_1016_j_mrfmmm_2020_111691 crossref_primary_10_1016_j_pbi_2012_08_004 crossref_primary_10_1002_csc2_20377 crossref_primary_10_1094_PHYTO_10_15_0279_R crossref_primary_10_1038_s41467_022_29267_8 crossref_primary_10_1016_j_tplants_2011_02_006 crossref_primary_10_1073_pnas_1817580116 crossref_primary_10_3390_genes11070787 crossref_primary_10_1007_s42994_023_00130_8 crossref_primary_10_1111_ele_12858 crossref_primary_10_1007_s00299_017_2098_z crossref_primary_10_1093_bfgp_elu009 crossref_primary_10_1093_bfgp_elu003 crossref_primary_10_1016_j_pbi_2012_10_003 crossref_primary_10_3389_fpls_2023_1305069 crossref_primary_10_1111_tpj_16482 crossref_primary_10_1104_pp_15_00291 crossref_primary_10_1111_mec_16168 crossref_primary_10_7554_eLife_06100 crossref_primary_10_1371_journal_pone_0213023 crossref_primary_10_1093_hr_uhad241 crossref_primary_10_1534_genetics_112_138461 crossref_primary_10_1371_journal_pgen_1009979 crossref_primary_10_1093_molbev_msaa150 crossref_primary_10_1111_jbi_14390 crossref_primary_10_1007_s10681_015_1630_x crossref_primary_10_1038_nature14649 crossref_primary_10_1038_s41467_021_24528_4 crossref_primary_10_7554_eLife_54898 crossref_primary_10_3390_biology2041357 crossref_primary_10_7554_eLife_70242 crossref_primary_10_1104_pp_110_167726 crossref_primary_10_1186_s13059_018_1516_z crossref_primary_10_1186_s13059_016_1127_5 crossref_primary_10_1016_j_mrgentox_2013_07_018 crossref_primary_10_1086_729053 crossref_primary_10_1093_molbev_msw102 crossref_primary_10_1371_journal_pgen_1006455 crossref_primary_10_1007_s11816_013_0285_0 crossref_primary_10_1111_nph_15434 crossref_primary_10_1038_nature14634 crossref_primary_10_3390_agronomy12112852 crossref_primary_10_1146_annurev_phyto_082718_095959 crossref_primary_10_3389_fpls_2022_958350 crossref_primary_10_1146_annurev_ecolsys_121415_032116 crossref_primary_10_1038_s41438_020_0305_5 crossref_primary_10_1186_1471_2229_13_29 crossref_primary_10_3389_fpls_2023_1056662 crossref_primary_10_1093_gigascience_giz027 crossref_primary_10_3390_ijms232314542 crossref_primary_10_1002_ps_4727 crossref_primary_10_7554_eLife_23907 crossref_primary_10_1111_mec_17232 crossref_primary_10_1016_j_jplph_2016_03_009 crossref_primary_10_1093_g3journal_jkab431 crossref_primary_10_1371_journal_pone_0094101 crossref_primary_10_1038_s41598_018_19278_1 crossref_primary_10_1093_bioinformatics_bts231 crossref_primary_10_1371_journal_pone_0096782 crossref_primary_10_1093_plphys_kiad640 crossref_primary_10_1016_j_tplants_2016_01_024 crossref_primary_10_1016_j_cub_2011_05_013 crossref_primary_10_1093_sysbio_syr120 crossref_primary_10_1002_evl3_8 crossref_primary_10_1111_evo_14152 crossref_primary_10_3390_ijms23020654 crossref_primary_10_1371_journal_pgen_1005588 crossref_primary_10_1186_1471_2164_13_20 crossref_primary_10_1093_pcp_pcac119 crossref_primary_10_1007_s10530_015_1001_5 crossref_primary_10_1007_s00438_022_01959_2 crossref_primary_10_1111_j_1365_294X_2011_05189_x crossref_primary_10_1111_nph_15243 crossref_primary_10_1104_pp_111_189845 crossref_primary_10_1073_pnas_1309843110 crossref_primary_10_3389_fgene_2020_00812 crossref_primary_10_2135_cropsci2019_01_0011 crossref_primary_10_1534_g3_116_030890 crossref_primary_10_1093_mp_sst165 crossref_primary_10_1007_s00425_012_1612_3 crossref_primary_10_1371_journal_pone_0075402 crossref_primary_10_1093_pcp_pcu153 crossref_primary_10_1186_1939_8433_6_4 crossref_primary_10_1270_jsbbs_17155 crossref_primary_10_1098_rstb_2013_0344 crossref_primary_10_1101_gr_140236_112 crossref_primary_10_3389_fgene_2022_979902 crossref_primary_10_1093_aob_mcr180 crossref_primary_10_1038_s41598_024_67190_8 crossref_primary_10_1093_molbev_msad238 crossref_primary_10_1186_1471_2164_13_72 crossref_primary_10_1111_mec_16587 crossref_primary_10_1093_sysbio_syz035 crossref_primary_10_1111_mec_15014 crossref_primary_10_1534_g3_114_011551 crossref_primary_10_3390_biology10080766 crossref_primary_10_1093_hr_uhae355 crossref_primary_10_1104_pp_114_238451 crossref_primary_10_1038_ng_2312 crossref_primary_10_1093_hr_uhad269 crossref_primary_10_1073_pnas_1311134110 crossref_primary_10_1111_j_1469_8137_2012_04061_x crossref_primary_10_1016_j_tig_2015_04_001 crossref_primary_10_1016_j_jplph_2021_153365 crossref_primary_10_1038_s41467_025_58021_z crossref_primary_10_1038_s41467_019_14213_y crossref_primary_10_1126_science_add1250 crossref_primary_10_3732_ajb_1100580 crossref_primary_10_1038_s41477_023_01538_2 crossref_primary_10_1093_molbev_msu345 crossref_primary_10_1038_s41477_017_0076_7 crossref_primary_10_1371_journal_pgen_1009987 crossref_primary_10_1101_gr_233551_117 crossref_primary_10_3390_su9010018 crossref_primary_10_1111_jbi_13230 crossref_primary_10_1111_nph_16308 crossref_primary_10_1534_genetics_111_128355 crossref_primary_10_7717_peerj_2889 crossref_primary_10_1186_s12864_017_4407_x crossref_primary_10_1093_molbev_msr281 crossref_primary_10_1016_j_plaphy_2011_07_006 crossref_primary_10_1111_jbi_13468 crossref_primary_10_1146_annurev_arplant_070522_054109 crossref_primary_10_1007_s10577_014_9420_1 crossref_primary_10_1038_s41437_021_00478_x crossref_primary_10_1093_pcp_pcae113 crossref_primary_10_1111_mec_12752 crossref_primary_10_1007_s00425_023_04176_2 crossref_primary_10_1007_s00438_013_0747_7 crossref_primary_10_1002_ece3_1378 crossref_primary_10_1038_s41559_024_02439_z crossref_primary_10_3732_ajb_1700054 crossref_primary_10_1073_pnas_2407821121 crossref_primary_10_1093_molbev_msr057 crossref_primary_10_1111_tpj_13262 crossref_primary_10_1093_molbev_msae247 crossref_primary_10_1016_j_cell_2020_04_019 crossref_primary_10_1111_nph_17560 crossref_primary_10_1186_2041_9139_4_26 crossref_primary_10_1007_s12041_013_0271_x crossref_primary_10_1111_tpj_16501 crossref_primary_10_1016_j_mimet_2013_04_007 crossref_primary_10_3389_fgeed_2023_1196763 crossref_primary_10_1093_genetics_iyab061 crossref_primary_10_1007_s00294_016_0573_7 crossref_primary_10_1093_gbe_evw164 crossref_primary_10_1266_ggs_14_00079 crossref_primary_10_1093_nar_gkv197 crossref_primary_10_1007_s11033_023_09086_w crossref_primary_10_1186_s13059_018_1458_5 crossref_primary_10_1126_sciadv_aay3240 crossref_primary_10_3390_ijms22168618 crossref_primary_10_1038_s41598_019_43141_6 crossref_primary_10_1038_s41477_017_0002_z crossref_primary_10_1093_molbev_mst218 crossref_primary_10_1093_molbev_msu306 crossref_primary_10_3390_ijms25105195 crossref_primary_10_3390_v13091800 crossref_primary_10_1016_j_cub_2011_07_002 crossref_primary_10_1007_s00122_022_04122_y crossref_primary_10_1007_s10265_014_0693_4 crossref_primary_10_1371_journal_pone_0065416 crossref_primary_10_3390_agriculture12050661 crossref_primary_10_1111_tpj_13243 crossref_primary_10_1093_plphys_kiae040 crossref_primary_10_1371_journal_pone_0058916 crossref_primary_10_1073_pnas_1912451117 crossref_primary_10_1002_ece3_1168 crossref_primary_10_1038_s41467_021_26108_y crossref_primary_10_1093_sysbio_syr012 crossref_primary_10_1534_genetics_118_300755 crossref_primary_10_3389_fgene_2021_682324 crossref_primary_10_1002_bies_201100075 crossref_primary_10_1093_molbev_msad185 crossref_primary_10_1101_gr_259853_119 crossref_primary_10_1073_pnas_1201043109 crossref_primary_10_1007_s13562_024_00942_9 crossref_primary_10_1101_gr_170696_113 crossref_primary_10_1093_gbe_evx068 crossref_primary_10_1186_s12864_017_4220_6 crossref_primary_10_1111_mec_17165 crossref_primary_10_3389_fgene_2014_00341 crossref_primary_10_1093_molbev_msr254 crossref_primary_10_1093_aobpla_plz076 crossref_primary_10_1111_nph_16035 crossref_primary_10_3390_ijms19123758 crossref_primary_10_1093_molbev_msr225 crossref_primary_10_1371_journal_pone_0162169 crossref_primary_10_3390_ijms24108825 crossref_primary_10_3390_f11121331 crossref_primary_10_1101_gr_271726_120 crossref_primary_10_1371_journal_pbio_3000265 crossref_primary_10_1016_j_cub_2019_07_025 crossref_primary_10_3389_fgeed_2022_937853 crossref_primary_10_3390_plants12142690 crossref_primary_10_1093_dnares_dsac008 crossref_primary_10_4137_EBO_S22566 crossref_primary_10_1093_dnares_dsac022 crossref_primary_10_1086_700104 crossref_primary_10_1534_genetics_114_169243 crossref_primary_10_1534_genetics_113_151670 crossref_primary_10_1101_gr_276992_122 crossref_primary_10_1101_gr_279378_124 crossref_primary_10_1093_pcp_pcw060 crossref_primary_10_3389_fpls_2020_00336 crossref_primary_10_1186_s12915_019_0702_0 crossref_primary_10_1111_j_1469_8137_2010_03401_x crossref_primary_10_1016_j_dnarep_2013_01_002 crossref_primary_10_1016_j_ijbiomac_2023_124064 crossref_primary_10_3390_ijms13089900 crossref_primary_10_1186_s13059_017_1342_8 crossref_primary_10_1002_ajb2_1633 crossref_primary_10_1007_s12041_013_0273_8 crossref_primary_10_1016_j_molp_2014_11_016 crossref_primary_10_1186_s12864_017_4218_0 crossref_primary_10_1186_s12870_018_1348_8 crossref_primary_10_1111_j_1558_5646_2011_01466_x crossref_primary_10_1007_s10142_011_0215_6 crossref_primary_10_1186_s12864_020_06804_7 crossref_primary_10_1038_s41467_019_11385_5 crossref_primary_10_3389_fpls_2019_00653 crossref_primary_10_1093_jxb_ery416 crossref_primary_10_1002_cppb_20040 crossref_primary_10_1146_annurev_genet_120116_024846 crossref_primary_10_1111_1755_0998_12163 crossref_primary_10_1016_j_ecolind_2022_109419 crossref_primary_10_3389_fpls_2023_1149083 crossref_primary_10_1111_tpj_13669 crossref_primary_10_3390_genes14071492 crossref_primary_10_1093_gbe_evt069 crossref_primary_10_1016_j_scitotenv_2022_156224 crossref_primary_10_1111_gcb_17622 crossref_primary_10_1086_663239 crossref_primary_10_1371_journal_pone_0164321 crossref_primary_10_1038_s41598_022_22486_5 crossref_primary_10_1134_S2079086413020059 crossref_primary_10_1186_s12862_016_0655_7 crossref_primary_10_3389_fpls_2019_01514 crossref_primary_10_1007_s00239_021_10040_2 crossref_primary_10_1038_s41437_020_00396_4 crossref_primary_10_1038_s41467_021_25681_6 crossref_primary_10_3390_ijms21249421 crossref_primary_10_1038_s41437_018_0095_9 crossref_primary_10_1007_s44154_021_00013_2 crossref_primary_10_3389_fpls_2022_948084 crossref_primary_10_1111_mec_12347 crossref_primary_10_1038_s41467_022_28800_z crossref_primary_10_3390_ijms21051720 crossref_primary_10_1016_j_tifs_2015_07_009 crossref_primary_10_1093_molbev_msz149 crossref_primary_10_7554_eLife_88456 crossref_primary_10_1093_molbev_msae099 crossref_primary_10_1093_evolut_qpae150 crossref_primary_10_1186_s12864_017_3980_3 crossref_primary_10_1111_j_1558_5646_2012_01583_x crossref_primary_10_1038_nrg3425 crossref_primary_10_1111_nph_12702 crossref_primary_10_1016_j_gene_2014_07_012 crossref_primary_10_1093_genetics_iyad074 crossref_primary_10_1093_evolut_qpae168 crossref_primary_10_1016_j_pbi_2015_01_008 crossref_primary_10_1093_molbev_msae087 crossref_primary_10_1186_s12864_015_2255_0 crossref_primary_10_1111_nph_12948 crossref_primary_10_1093_sysbio_syt032 crossref_primary_10_1186_s12864_019_6211_2 crossref_primary_10_3389_fpls_2021_683043 crossref_primary_10_1111_j_1365_313X_2011_04590_x crossref_primary_10_1080_07352689_2021_1883826 crossref_primary_10_1101_gr_183905_114 crossref_primary_10_1186_s12864_015_1402_y crossref_primary_10_1038_s42003_018_0168_6 crossref_primary_10_1186_s12915_021_01079_0 crossref_primary_10_3389_fpls_2020_574959 crossref_primary_10_1104_pp_111_174912 crossref_primary_10_1016_j_tig_2012_10_009 crossref_primary_10_1186_s12864_015_1974_6 crossref_primary_10_1038_s41437_024_00683_4 crossref_primary_10_3390_d8040029 crossref_primary_10_1111_1755_0998_13291 crossref_primary_10_1186_s13059_024_03337_0 crossref_primary_10_1111_mec_14738 crossref_primary_10_1371_journal_pone_0068310 crossref_primary_10_1016_j_tibs_2021_05_006 crossref_primary_10_1016_j_ppees_2024_125800 crossref_primary_10_1093_gbe_evx222 crossref_primary_10_1534_g3_111_000539 crossref_primary_10_1016_j_mrrev_2011_11_002 crossref_primary_10_1146_annurev_ecolsys_112414_054249 crossref_primary_10_1093_molbev_msx193 crossref_primary_10_1007_s11816_016_0418_3 crossref_primary_10_1186_s13059_020_02161_6 crossref_primary_10_1038_ncomms15275 crossref_primary_10_1016_j_cellin_2024_100209 crossref_primary_10_3389_fpls_2019_00236 crossref_primary_10_1101_gr_204669_116 crossref_primary_10_3389_fpls_2022_823372 crossref_primary_10_1186_s12864_016_3034_2 crossref_primary_10_1038_s41598_021_82731_1 crossref_primary_10_1111_evo_12858 crossref_primary_10_3389_fevo_2016_00086 crossref_primary_10_1007_s13258_018_0754_5 crossref_primary_10_1073_pnas_2011361117 crossref_primary_10_1016_j_molp_2022_07_003 crossref_primary_10_1038_s41598_017_14738_6 crossref_primary_10_1093_molbev_msx180 crossref_primary_10_1002_ece3_722 crossref_primary_10_7554_eLife_01426 crossref_primary_10_1371_journal_pbio_2005439 crossref_primary_10_1093_gbe_evx203 crossref_primary_10_1111_tpj_12754 crossref_primary_10_1007_s11248_014_9843_7 crossref_primary_10_1093_gbe_evx206 crossref_primary_10_1038_s41437_021_00417_w crossref_primary_10_1111_mec_16207 crossref_primary_10_1073_pnas_2119720119 crossref_primary_10_3389_fpls_2017_01851 crossref_primary_10_1111_1755_0998_13529 crossref_primary_10_1093_bfgp_elr046 crossref_primary_10_1186_s12864_018_4874_8 crossref_primary_10_3390_toxins9060183 crossref_primary_10_1111_evo_12913 crossref_primary_10_1002_ece3_4085 crossref_primary_10_1016_j_gde_2012_01_007 crossref_primary_10_3389_fgene_2015_00004 crossref_primary_10_1016_j_pbi_2012_01_002 crossref_primary_10_1038_nature10555 crossref_primary_10_1038_s41467_020_20606_1 crossref_primary_10_1007_s11627_021_10213_0 crossref_primary_10_1093_molbev_msaa200 crossref_primary_10_1134_S1021443716020059 crossref_primary_10_1038_ng_807 crossref_primary_10_1093_molbev_msz304 crossref_primary_10_1093_gbe_evr032 crossref_primary_10_1007_s10265_023_01452_w crossref_primary_10_1371_journal_ppat_1002146 crossref_primary_10_1002_evl3_121 crossref_primary_10_1002_wsbm_1411 crossref_primary_10_1186_s13059_021_02381_4 crossref_primary_10_1111_evo_12937 crossref_primary_10_1266_ggs_87_145 crossref_primary_10_3390_genes12050621 crossref_primary_10_1186_s13059_019_1729_9 crossref_primary_10_3389_fpls_2023_1331258 crossref_primary_10_1111_j_1365_313X_2011_04852_x crossref_primary_10_1534_genetics_120_303028 crossref_primary_10_1038_s41467_018_06983_8 crossref_primary_10_1534_genetics_115_176834 crossref_primary_10_1016_j_tig_2010_12_003 crossref_primary_10_3389_fpls_2019_01815 crossref_primary_10_1007_s11103_011_9852_3 crossref_primary_10_1007_s00122_016_2708_0 crossref_primary_10_1146_annurev_ecolsys_102710_145119 crossref_primary_10_1111_jse_12849 crossref_primary_10_1111_eva_12704 crossref_primary_10_1111_tpj_16169 crossref_primary_10_1016_j_heliyon_2023_e20231 crossref_primary_10_1073_pnas_1210663109 crossref_primary_10_1073_pnas_2023801118 crossref_primary_10_1534_g3_116_030130 crossref_primary_10_1111_pbr_12117 crossref_primary_10_1093_molbev_msu073 crossref_primary_10_1093_mp_ssr022 crossref_primary_10_1093_molbev_msv161 crossref_primary_10_1534_g3_117_040204 crossref_primary_10_1016_j_xplc_2020_100115 crossref_primary_10_1038_nmicrobiol_2016_45 crossref_primary_10_1038_nrg_2017_45 crossref_primary_10_1016_j_algal_2020_101989 crossref_primary_10_3390_genes13101799 crossref_primary_10_1111_j_1469_8137_2012_04378_x crossref_primary_10_1007_s11240_022_02378_2 crossref_primary_10_1111_jeb_12384 crossref_primary_10_2135_cropsci2017_03_0199 crossref_primary_10_1093_gbe_evr085 crossref_primary_10_1093_molbev_msw024 crossref_primary_10_1371_journal_pone_0096879 crossref_primary_10_1186_1471_2148_14_41 crossref_primary_10_1093_molbev_msx119 crossref_primary_10_1093_dnares_dst036 crossref_primary_10_1073_pnas_1321152111 crossref_primary_10_1186_s12864_018_5081_3 crossref_primary_10_1016_j_jafr_2024_101132 crossref_primary_10_1534_g3_117_043984 crossref_primary_10_1002_1438_390X_12018 crossref_primary_10_1093_nar_gkw647 crossref_primary_10_1631_jzus_B1600125 crossref_primary_10_1371_journal_pgen_1009477 crossref_primary_10_1093_molbev_msw234 crossref_primary_10_1371_journal_pgen_1011312 crossref_primary_10_1073_pnas_2022713118 crossref_primary_10_1186_s13059_017_1288_x crossref_primary_10_7554_eLife_70339 crossref_primary_10_1038_s41467_018_04344_z crossref_primary_10_1371_journal_pgen_1000890 crossref_primary_10_7554_eLife_88456_3 crossref_primary_10_1007_s11434_013_0057_9 crossref_primary_10_1098_rspb_2019_2364 crossref_primary_10_3389_fpls_2019_01612 crossref_primary_10_3389_fpls_2021_602598 crossref_primary_10_1093_pcp_pcr172 crossref_primary_10_1111_jbi_14282 crossref_primary_10_1371_journal_pgen_1002838 crossref_primary_10_3389_fpls_2019_00525 crossref_primary_10_1007_s00606_014_1088_7 crossref_primary_10_1016_j_tifs_2019_03_007 crossref_primary_10_1038_s41477_024_01678_z crossref_primary_10_1002_ece3_8834 crossref_primary_10_3389_fpls_2023_1227219 crossref_primary_10_1016_j_tig_2019_01_002 crossref_primary_10_1016_j_cub_2011_11_054 crossref_primary_10_1093_molbev_msx300 crossref_primary_10_1038_srep39843 crossref_primary_10_1093_molbev_mss093 crossref_primary_10_1073_pnas_1900870116 crossref_primary_10_1093_nar_gkt1376 crossref_primary_10_1093_gbe_evaa160 crossref_primary_10_3389_fpls_2023_1157145 crossref_primary_10_1017_wsc_2019_19 crossref_primary_10_1266_ggs_18_00039 crossref_primary_10_1038_s42003_022_04106_0 crossref_primary_10_1073_pnas_1617483114 crossref_primary_10_1080_09553002_2024_2345087 crossref_primary_10_1016_j_cub_2020_09_019 crossref_primary_10_1093_molbev_msw224 crossref_primary_10_1038_s41467_018_02839_3 crossref_primary_10_1111_1755_0998_12604 crossref_primary_10_1093_molbev_msw226 crossref_primary_10_1111_mec_12907 crossref_primary_10_1111_mec_14097 crossref_primary_10_1007_s00122_013_2177_7 crossref_primary_10_1186_s12864_016_3459_7 crossref_primary_10_1093_hr_uhac029 crossref_primary_10_1101_gr_131474_111 crossref_primary_10_1111_pbi_14370 crossref_primary_10_1038_ng_2684 crossref_primary_10_1038_s41467_020_16679_7 crossref_primary_10_1007_s00438_010_0570_3 crossref_primary_10_1093_treephys_tpac058 crossref_primary_10_1007_s00334_016_0597_4 crossref_primary_10_1101_gr_191338_115 crossref_primary_10_1101_gr_191494_115 crossref_primary_10_1038_s41467_024_52612_y crossref_primary_10_1111_mec_17356 crossref_primary_10_9787_PBB_2018_6_4_426 crossref_primary_10_1038_s41586_023_06315_x crossref_primary_10_1016_j_jgg_2021_12_009 crossref_primary_10_1038_s41559_017_0119 crossref_primary_10_1093_molbev_msab140 crossref_primary_10_1111_tpj_16592 crossref_primary_10_1002_tpg2_20162 crossref_primary_10_1104_pp_110_166736 crossref_primary_10_1038_s41477_017_0066_9 crossref_primary_10_1038_s41467_019_09235_5 crossref_primary_10_1016_j_isci_2024_109159 crossref_primary_10_1093_molbev_msv119 crossref_primary_10_1111_mec_17343 crossref_primary_10_3390_ijms25052795 crossref_primary_10_3897_zse_100_119945 crossref_primary_10_1093_gbe_evz140 crossref_primary_10_1007_s12041_014_0402_z crossref_primary_10_1002_tax_13288 crossref_primary_10_1016_j_bbrc_2011_05_017 crossref_primary_10_1371_journal_pone_0121056 crossref_primary_10_1007_s13580_020_00237_7 crossref_primary_10_1007_s11103_013_0083_7 crossref_primary_10_17660_ActaHortic_2024_1405_17 crossref_primary_10_17660_ActaHortic_2024_1405_15 crossref_primary_10_1111_jse_12493 crossref_primary_10_1086_661783 crossref_primary_10_1111_tpj_70006 crossref_primary_10_1093_bioinformatics_btaa716 crossref_primary_10_1104_pp_111_192062 crossref_primary_10_7554_eLife_43606 crossref_primary_10_3389_fpls_2021_707740 crossref_primary_10_1111_j_1467_7652_2012_00733_x crossref_primary_10_1038_nbt_2347 crossref_primary_10_1016_j_bse_2016_03_011 crossref_primary_10_1093_molbev_msab162 crossref_primary_10_1111_evo_14208 crossref_primary_10_1534_genetics_112_145078 crossref_primary_10_1016_j_tplants_2012_01_001 crossref_primary_10_1007_s00438_017_1405_2 crossref_primary_10_1007_s12033_011_9443_1 crossref_primary_10_1016_j_mrfmmm_2011_10_001 crossref_primary_10_1016_j_tplants_2012_01_006 crossref_primary_10_1111_pbr_12526 crossref_primary_10_1093_gbe_evaa131 crossref_primary_10_1098_rspb_2016_1016 crossref_primary_10_1093_molbev_msu247 crossref_primary_10_1186_1471_2164_14_56 crossref_primary_10_7554_eLife_82384 crossref_primary_10_1038_ncomms13522 crossref_primary_10_1038_s41467_021_24364_6 crossref_primary_10_1073_pnas_1011987107 crossref_primary_10_1146_annurev_cellbio_111822_014426 crossref_primary_10_1111_tpj_70029 crossref_primary_10_1111_mec_16226 crossref_primary_10_1007_s10722_021_01282_6 crossref_primary_10_1186_1471_2164_14_594 crossref_primary_10_1073_pnas_1216223109 crossref_primary_10_3389_fbioe_2018_00213 crossref_primary_10_1111_evo_12286 crossref_primary_10_1007_s11295_016_1084_x crossref_primary_10_34133_2020_8051764 crossref_primary_10_3390_genes10090671 crossref_primary_10_1038_s41477_019_0486_9 crossref_primary_10_1007_s10725_014_0012_z crossref_primary_10_1093_molbev_msad105 crossref_primary_10_1111_j_1365_294X_2011_05340_x crossref_primary_10_1093_molbev_msac015 crossref_primary_10_3390_plants13101400 crossref_primary_10_1016_j_molp_2015_01_021 crossref_primary_10_1105_tpc_114_130310 crossref_primary_10_1111_mec_16454 crossref_primary_10_1098_rspb_2023_0565 crossref_primary_10_1534_genetics_115_177329 crossref_primary_10_1111_1365_2745_12347 crossref_primary_10_1080_13102818_2021_1911684 crossref_primary_10_1038_nbt_3208 crossref_primary_10_1038_ng_2669 crossref_primary_10_1038_s41437_021_00441_w crossref_primary_10_1111_mec_13183 crossref_primary_10_1111_nph_16669 crossref_primary_10_14252_foodsafetyfscj_D_21_00016 |
| Cites_doi | 10.1073/pnas.0904895106 10.1073/pnas.96.20.11393 10.1038/274775a0 10.1038/35048692 10.1101/gr.080200.108 10.1126/science.1138632 10.1093/oxfordjournals.molbev.a004204 10.1021/bi00713a035 10.1073/pnas.0803466105 10.1186/gb-2009-10-9-r98 10.1093/genetics/155.1.369 10.1038/nmeth.1270 10.1093/molbev/msn185 10.1073/pnas.84.24.9054 10.1016/j.cell.2008.03.029 10.1534/genetics.107.085282 10.1038/hdy.2009.67 10.1038/287560a0 10.1038/nature06745 10.1101/gr.091231.109 |
| ContentType | Journal Article |
| Copyright | Copyright 2010 American Association for the Advancement of Science 2015 INIST-CNRS Copyright © 2010, American Association for the Advancement of Science Copyright 2010 by the American Association for the Advancement of Science; all rights reserved. 2010 |
| Copyright_xml | – notice: Copyright 2010 American Association for the Advancement of Science – notice: 2015 INIST-CNRS – notice: Copyright © 2010, American Association for the Advancement of Science – notice: Copyright 2010 by the American Association for the Advancement of Science; all rights reserved. 2010 |
| DBID | FBQ AAYXX CITATION IQODW CGR CUY CVF ECM EIF NPM 7QF 7QG 7QL 7QP 7QQ 7QR 7SC 7SE 7SN 7SP 7SR 7SS 7T7 7TA 7TB 7TK 7TM 7U5 7U9 8BQ 8FD C1K F28 FR3 H8D H8G H94 JG9 JQ2 K9. KR7 L7M L~C L~D M7N P64 RC3 7S9 L.6 7X8 5PM |
| DOI | 10.1126/science.1180677 |
| DatabaseName | AGRIS CrossRef Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Aluminium Industry Abstracts Animal Behavior Abstracts Bacteriology Abstracts (Microbiology B) Calcium & Calcified Tissue Abstracts Ceramic Abstracts Chemoreception Abstracts Computer and Information Systems Abstracts Corrosion Abstracts Ecology Abstracts Electronics & Communications Abstracts Engineered Materials Abstracts Entomology Abstracts (Full archive) Industrial and Applied Microbiology Abstracts (Microbiology A) Materials Business File Mechanical & Transportation Engineering Abstracts Neurosciences Abstracts Nucleic Acids Abstracts Solid State and Superconductivity Abstracts Virology and AIDS Abstracts METADEX Technology Research Database Environmental Sciences and Pollution Management ANTE: Abstracts in New Technology & Engineering Engineering Research Database Aerospace Database Copper Technical Reference Library AIDS and Cancer Research Abstracts Materials Research Database ProQuest Computer Science Collection ProQuest Health & Medical Complete (Alumni) Civil Engineering Abstracts Advanced Technologies Database with Aerospace Computer and Information Systems Abstracts Academic Computer and Information Systems Abstracts Professional Algology Mycology and Protozoology Abstracts (Microbiology C) Biotechnology and BioEngineering Abstracts Genetics Abstracts AGRICOLA AGRICOLA - Academic MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Materials Research Database Technology Research Database Computer and Information Systems Abstracts – Academic Mechanical & Transportation Engineering Abstracts Nucleic Acids Abstracts ProQuest Computer Science Collection Computer and Information Systems Abstracts ProQuest Health & Medical Complete (Alumni) Materials Business File Environmental Sciences and Pollution Management Aerospace Database Copper Technical Reference Library Engineered Materials Abstracts Genetics Abstracts Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) AIDS and Cancer Research Abstracts Chemoreception Abstracts Industrial and Applied Microbiology Abstracts (Microbiology A) Advanced Technologies Database with Aerospace ANTE: Abstracts in New Technology & Engineering Civil Engineering Abstracts Aluminium Industry Abstracts Virology and AIDS Abstracts Electronics & Communications Abstracts Ceramic Abstracts Ecology Abstracts Neurosciences Abstracts METADEX Biotechnology and BioEngineering Abstracts Computer and Information Systems Abstracts Professional Entomology Abstracts Animal Behavior Abstracts Solid State and Superconductivity Abstracts Engineering Research Database Calcium & Calcified Tissue Abstracts Corrosion Abstracts AGRICOLA AGRICOLA - Academic MEDLINE - Academic |
| DatabaseTitleList | AGRICOLA CrossRef MEDLINE Technology Research Database MEDLINE - Academic Materials Research Database |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 3 dbid: FBQ name: AGRIS url: http://www.fao.org/agris/Centre.asp?Menu_1ID=DB&Menu_2ID=DB1&Language=EN&Content=http://www.fao.org/agris/search?Language=EN sourceTypes: Publisher |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Sciences (General) Biology |
| EISSN | 1095-9203 |
| EndPage | 94 |
| ExternalDocumentID | PMC3878865 1927070321 20044577 22280699 10_1126_science_1180677 40508300 US201301720594 |
| Genre | Research Support, U.S. Gov't, Non-P.H.S Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural Feature |
| GrantInformation_xml | – fundername: NIGMS NIH HHS grantid: R01 GM036827 – fundername: NIGMS NIH HHS grantid: GM36827 – fundername: National Institute of General Medical Sciences : NIGMS grantid: R01 GM036827 || GM |
| GroupedDBID | --- --Z -DZ -ET -~X .-4 ..I .55 .DC .GJ .GO .HR 0-V 08G 0B8 0R~ 0WA 123 186 18M 2FS 2KS 2WC 2XV 34G 36B 39C 3EH 3R3 3V. 4.4 41~ 42X 4R4 53G 5RE 63O 66. 68V 692 6OB 6TJ 79B 7X2 7X7 7XC 7~K 85S 88A 88E 88I 8AF 8CJ 8F7 8FE 8FG 8FH 8FI 8FJ 8G5 8GL 8WZ 97F A6W AABCJ AACGO AADHG AAFWJ AAIKC AAJYS AAKAS AAMNW AANCE AAWTO AAYJJ AAYOK ABBHK ABCQX ABDBF ABDEX ABEFU ABIVO ABJCF ABOCM ABPLY ABPMR ABPPZ ABPTK ABQIJ ABTAH ABTLG ABUWG ABWJO ABZEH ACBEA ACBEC ACGFO ACGFS ACGOD ACIWK ACMJI ACNCT ACPRK ACQAM ACQOY ACTDY ADBBV ADDRP ADMHC ADULT ADZCM ADZLD AEGBM AENEX AETEA AEUPB AEXZC AFCHL AFDAS AFFDN AFFNX AFHKK AFKRA AFOSN AFQFN AFRAH AGCDD AGFXO AGNAY AGSOS AHMBA AIDAL AIDUJ AJGZS AJUXI ALMA_UNASSIGNED_HOLDINGS ALSLI ANJGP ARALO ARAPS ASPBG ATCPS AVWKF AZQEC B-7 BBNVY BBWZM BCU BEC BENPR BGLVJ BHPHI BKF BKNYI BKSAR BLC BPHCQ BVXVI C2- C45 C51 CCPQU CJNVE CS3 D0S D1I D1J D1K DB2 DCCCD DNJUQ DOOOF DU5 DWIUU DWQXO D~A EAU EBS EGS EJD EMOBN ESX EWM EX3 F20 F5P FA8 FBQ FEDTE FYUFA G8K GICCO GNUQQ GUQSH GX1 HCIFZ HGD HMCUK HQ3 HTVGU HVGLF HZ~ I.T IAG IAO IBG IEA IEP IER IGG IGS IH2 IHR INH INR IOF IOV IPC IPO IPY ISE ISN ISR ITC J5H J9C JAAYA JBMMH JCF JENOY JHFFW JKQEH JLS JLXEF JPM JSG JSODD JST K-O K6- K9- KB. KCC KQ8 L6V L7B LK5 LK8 LPU LSO LU7 M0K M0L M0P M0R M1P M2O M2P M2Q M7P M7R M7S MQT MVM N4W N9A NEJ NHB O9- OCB OFXIZ OGEVE OK1 OMK OVD P-O P2P P62 PATMY PCBAR PDBOC PK8 PQQKQ PROAC PSQYO PTHSS PV9 PYCSY PZZ QJJ QS- R05 RHF RHI RNS RXW RZL SA0 SC5 SJFOW SJN SKT TAE TEORI TN5 TWZ UBW UBY UCV UHB UHU UKHRP UKR UMD UNMZH UQL USG VOH VQA VVN WH7 WI4 WOQ WOW X7L X7M XFK XIH XJF XKJ XOL XZL Y6R YCJ YJ6 YK4 YKV YNT YOJ YR2 YRY YSQ YV5 YWH YXB YYP YYQ YZZ ZA5 ZCA ZCF ZCG ZE2 ZGI ZKG ZVL ZVM ZXP ZY4 ~02 ~G0 ~H1 ~KM ~ZZ ABDQB ABJNI ABXSQ ACHIC ACUHS ADQXQ ADUKH ADXHL AFBNE ALIPV AQVQM IPSME YR5 AAYXX ABDPE AEUYN AFQQW CITATION PHGZM PHGZT PQEDU IQODW PJZUB PPXIY PQGLB CGR CUY CVF ECM EIF NPM 7QF 7QG 7QL 7QP 7QQ 7QR 7SC 7SE 7SN 7SP 7SR 7SS 7T7 7TA 7TB 7TK 7TM 7U5 7U9 8BQ 8FD C1K F28 FR3 H8D H8G H94 JG9 JQ2 K9. KR7 L7M L~C L~D M7N P64 RC3 7S9 L.6 7X8 5PM |
| ID | FETCH-LOGICAL-c586t-aef23f55e8cb631876aa6b00f4e8fea20987a4457f1e3b6e8aca035bd427dde03 |
| ISSN | 0036-8075 1095-9203 |
| IngestDate | Thu Aug 21 17:50:28 EDT 2025 Fri Jul 11 04:50:34 EDT 2025 Fri Jul 11 15:21:14 EDT 2025 Thu Jul 10 22:47:46 EDT 2025 Fri Jul 25 10:33:46 EDT 2025 Mon Jul 21 05:55:45 EDT 2025 Mon Jul 21 09:11:09 EDT 2025 Tue Jul 01 03:11:33 EDT 2025 Thu Apr 24 23:08:48 EDT 2025 Thu Jul 03 21:21:12 EDT 2025 Wed Dec 27 19:09:04 EST 2023 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 5961 |
| Keywords | Single seed descent Divergence Spontaneous Arabidopsis thaliana Ultraviolet radiation Mutagenesis Substitution Cruciferae Dicotyledones Angiospermae Deletion Chromosome DNA Spermatophyta Cytosine Mutation Experimental plant Genome Methylation Polymorphism |
| Language | English |
| License | CC BY 4.0 |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c586t-aef23f55e8cb631876aa6b00f4e8fea20987a4457f1e3b6e8aca035bd427dde03 |
| Notes | SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 14 ObjectType-Article-2 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 These authors contributed equally to this work. |
| OpenAccessLink | http://hdl.handle.net/10550/44819 |
| PMID | 20044577 |
| PQID | 213605241 |
| PQPubID | 1256 |
| PageCount | 3 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_3878865 proquest_miscellaneous_734219131 proquest_miscellaneous_46458846 proquest_miscellaneous_36426867 proquest_journals_213605241 pubmed_primary_20044577 pascalfrancis_primary_22280699 crossref_primary_10_1126_science_1180677 crossref_citationtrail_10_1126_science_1180677 jstor_primary_40508300 fao_agris_US201301720594 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2010 20100101 2010-01-00 2010-Jan-01 |
| PublicationDateYYYYMMDD | 2010-01-01 |
| PublicationDate_xml | – year: 2010 text: 2010 |
| PublicationDecade | 2010 |
| PublicationPlace | Washington, DC |
| PublicationPlace_xml | – name: Washington, DC – name: United States – name: Washington |
| PublicationTitle | Science (American Association for the Advancement of Science) |
| PublicationTitleAlternate | Science |
| PublicationYear | 2010 |
| Publisher | American Association for the Advancement of Science The American Association for the Advancement of Science |
| Publisher_xml | – name: American Association for the Advancement of Science – name: The American Association for the Advancement of Science |
| References | e_1_3_2_8_2 e_1_3_2_7_2 e_1_3_2_17_2 e_1_3_2_6_2 Wright S. I. (e_1_3_2_16_2) 2002; 19 e_1_3_2_18_2 e_1_3_2_19_2 e_1_3_2_20_2 e_1_3_2_10_2 e_1_3_2_21_2 e_1_3_2_11_2 e_1_3_2_22_2 e_1_3_2_4_2 e_1_3_2_12_2 e_1_3_2_23_2 e_1_3_2_3_2 e_1_3_2_13_2 e_1_3_2_24_2 e_1_3_2_2_2 e_1_3_2_14_2 Shaw F. H. (e_1_3_2_15_2) 2002; 56 Shaw R. G. (e_1_3_2_5_2) 2000; 155 |
| References_xml | – ident: e_1_3_2_3_2 doi: 10.1073/pnas.0904895106 – ident: e_1_3_2_14_2 doi: 10.1073/pnas.96.20.11393 – ident: e_1_3_2_19_2 doi: 10.1038/274775a0 – ident: e_1_3_2_6_2 doi: 10.1038/35048692 – ident: e_1_3_2_7_2 doi: 10.1101/gr.080200.108 – ident: e_1_3_2_17_2 doi: 10.1126/science.1138632 – ident: e_1_3_2_23_2 – volume: 19 start-page: 1407 year: 2002 ident: e_1_3_2_16_2 article-title: Rates and patterns of molecular evolution in inbred and outbred Arabidopsis. publication-title: Mol. Biol. Evol. doi: 10.1093/oxfordjournals.molbev.a004204 – ident: e_1_3_2_18_2 doi: 10.1021/bi00713a035 – ident: e_1_3_2_2_2 doi: 10.1073/pnas.0803466105 – ident: e_1_3_2_8_2 doi: 10.1186/gb-2009-10-9-r98 – volume: 155 start-page: 369 year: 2000 ident: e_1_3_2_5_2 article-title: Spontaneous mutational effects on reproductive traits of Arabidopsis thaliana. publication-title: Genetics doi: 10.1093/genetics/155.1.369 – ident: e_1_3_2_11_2 doi: 10.1038/nmeth.1270 – ident: e_1_3_2_10_2 doi: 10.1093/molbev/msn185 – ident: e_1_3_2_13_2 doi: 10.1073/pnas.84.24.9054 – ident: e_1_3_2_22_2 doi: 10.1016/j.cell.2008.03.029 – ident: e_1_3_2_24_2 doi: 10.1534/genetics.107.085282 – ident: e_1_3_2_12_2 doi: 10.1038/hdy.2009.67 – volume: 56 start-page: 453 year: 2002 ident: e_1_3_2_15_2 article-title: A comprehensive model of mutations affecting fitness and inferences for Arabidopsis thaliana. publication-title: Evolution – ident: e_1_3_2_20_2 doi: 10.1038/287560a0 – ident: e_1_3_2_21_2 doi: 10.1038/nature06745 – ident: e_1_3_2_4_2 doi: 10.1101/gr.091231.109 |
| SSID | ssj0009593 |
| Score | 2.5494149 |
| Snippet | To take complete advantage of information on within-species polymorphism and divergence from close relatives, one needs to know the rate and the molecular... Rates of evolution in gene and genome sequences have been estimated, but these estimates are subject to error because many of the steps of evolution over the... |
| SourceID | pubmedcentral proquest pubmed pascalfrancis crossref jstor fao |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 92 |
| SubjectTerms | Agronomy. Soil science and plant productions Arabidopsis - genetics Arabidopsis - radiation effects Arabidopsis thaliana Biological and medical sciences Cytosine - metabolism Deamination DNA Methylation DNA, Intergenic DNA, Plant - genetics Flowers & plants Fundamental and applied biological sciences. Psychology Genetic mutation Genetics and breeding of economic plants genome Genome, Plant Genomes Genomics INDEL Mutation Intergenic DNA Introns Methylation Molecular biology Molecular spectra Mutagenesis Mutation Natural selection Plant biology Plant breeding: fundamental aspects and methodology Polymorphism Sequence Analysis, DNA Sequence Deletion Sequencing Ultraviolet radiation Ultraviolet Rays Untranslated regions |
| Title | Rate and Molecular Spectrum of Spontaneous Mutations in Arabidopsis thaliana |
| URI | https://www.jstor.org/stable/40508300 https://www.ncbi.nlm.nih.gov/pubmed/20044577 https://www.proquest.com/docview/213605241 https://www.proquest.com/docview/36426867 https://www.proquest.com/docview/46458846 https://www.proquest.com/docview/734219131 https://pubmed.ncbi.nlm.nih.gov/PMC3878865 |
| Volume | 327 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Bb5swFLbSVpN2mdZuXVm3zocdOk1UBGMDxyRNla5JOpVG6w0ZYreRVhIl5LD91v2YPWNDSNdo6y4oAgOB78PvPfvzewh9pCpKlmxs04A5tscJgW9OCttrSh7QhIaiyFMwGLLeyPtyQ28ajV811dIyT07Sn4-uK_kfVGEf4KpWyT4B2eqisAN-A76wBYRh-88YX4GzqNUSZaHboqZ8Pl_eFwtSZtMM_D-hlK6DZb6SjrfmPJmMpzOVkCS_K0Y7eN1TLT968ECrWZ0alpU8saVFBKWmwJxWH76Nostv0cV5pSlb8THq9Ibdbrt7ZfQYF9M5BOo1wvZHnVZk9_vd00szXaEn9j-f32Y81RKywqSAW94btIZDMxV1by5hhjOMpHW1duBJz1Lv2E1e5XrHTnTWAcNgGuqs76an1hX4jM3XdZb_tCa1-pfiRCXLY6bmzFre7gf2tFI5qsE1h4XhFtpxIYgBs7HTap-2zzYmhTapp2qLusqbrnlNW5JPS_ms0vLyBXzOUtdheSxQeqj3rTlQ1y_RCxP54Jam8S5qiGwPPdO1UH_soV3zthf42KRC__QKfQWGY8VwDAzHFcNxyXA8lbjGcFwxHE8yXGM4Lhn-Go3Outednm1qgNgp9B65zYV0iaRUBGnCwP74jHMGpkJ6IpCCu04Y-NzzqC-bgiRMBDzlDqHJ2HN9sNwO2Ufb2TQTBwj70vNSkVCFiddMghBeuySCeYXlkq6FTsp3HKcmQb6q0_I9LgJll8UGlNiAYqHj6oSZzg2zuekBgBbzW7Dc8ShylV4AQgeVLMlC-wWS1SUghIK4yHEsdLQGbdWg5JWFDkusY9MrLWK3SZhDwS-30IfqKJgMNQ-osYgJA7c8YP7mFkruEEBkYiG8oYVPPPB1mgRu80aTa_X3lEiEqmf212hXNVAZ7dePZJO7IrM9CfwgYPTt3578ED3XKh41FPoObQPjxHsIDvLkyHxjvwFK-xG4 |
| linkProvider | EBSCOhost |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+Rate+and+Molecular+Spectrum+of+Spontaneous+Mutations+in+Arabidopsis+thaliana&rft.jtitle=Science+%28American+Association+for+the+Advancement+of+Science%29&rft.au=OSSOWSKI%2C+Stephan&rft.au=SCHNEEBERGER%2C+Korbinian&rft.au=LUCAS-LLEDO%2C+Jos%C3%A9+Ignacio&rft.au=WARTHMANN%2C+Norman&rft.date=2010&rft.pub=American+Association+for+the+Advancement+of+Science&rft.issn=0036-8075&rft.volume=327&rft.issue=5961&rft.spage=92&rft.epage=94&rft_id=info:doi/10.1126%2Fscience.1180677&rft.externalDBID=n%2Fa&rft.externalDocID=22280699 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0036-8075&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0036-8075&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0036-8075&client=summon |