Enzymatic deglycation of Amadori products in bacteria: mechanisms, occurrence and physiological functions

• Published in: Applied microbiology and biotechnology Vol. 90; no. 2; pp. 399 - 406
• Main Authors: Deppe, Veronika Maria, Bongaerts, Johannes, O'Connell, Timothy, Maurer, Karl-Heinz, Meinhardt, Friedhelm
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Berlin/Heidelberg : Springer-Verlag 01.04.2011; Springer-Verlag; Springer; Springer Nature B.V
• Subjects: ABC transporter; ABC transporters; Amadori products; Amino acids; Bacillus subtilis; Bacillus subtilis - enzymology; Bacteria; Bacterial Proteins; Bacterial Proteins - metabolism; Biodegradation; Biological and medical sciences; Biomedical and Life Sciences; Biosynthesis; Biotechnology; carbon; chemistry; Decomposition; Deglycation; E coli; Enzymes; enzymology; Escherichia coli; Escherichia coli - enzymology; Fructosamine; Fructosamine - chemistry; Fructosamines; Fundamental and applied biological sciences. Psychology; Genes; Genomes; Glucose; glycation; Glycation End Products, Advanced - metabolism; Glycosylation End Products, Advanced; Kinases; Life Sciences; Maillard reaction; mammals; metabolism; Microbial Genetics and Genomics; Microbiology; Mini-Review; nitrogen; Nitrogen sources; Phosphatase; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Phosphotransferases (Alcohol Group Acceptor) - metabolism; Physiology; Proteins; Studies; Substrate Specificity; toxicity; Maillard reaction; Fructosamines; Deglycation; Bacteria; Physiology; Mechanism

Amadori products (fructosamines)--ubiquitously occurring in nature--are precursors of the toxic and cell damaging ‘advanced glycation endproducts'; thus, it is not surprising that numerous organisms have developed systems to degrade such compounds. The deglycating enzymes differ with respect to...