Neuropathy of haematopoietic stem cell niche is essential for myeloproliferative neoplasms

• Published in: Nature (London) Vol. 512; no. 7512; pp. 78 - 81
• Main Authors: Arranz, Lorena, Sánchez-Aguilera, Abel, Martín-Pérez, Daniel, Isern, Joan, Langa, Xavier, Tzankov, Alexandar, Lundberg, Pontus, Muntión, Sandra, Tzeng, Yi-Shiuan, Lai, Dar-Ming, Schwaller, Jürg, Skoda, Radek C., Méndez-Ferrer, Simón
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 07.08.2014; Nature Publishing Group
• Subjects: 13/1; 13/100; 13/106; 13/2; 13/21; 13/31; 13/51; 14/19; 14/63; 631/532/2139; 631/67/327; 64/110; 64/60; Adrenergic beta-3 Receptor Agonists - pharmacology; Adrenergic beta-3 Receptor Agonists - therapeutic use; Animals; Apoptosis; Apoptosis - drug effects; Bone marrow; Complications and side effects; Development and progression; Disease Progression; Female; Fibers; Health aspects; Hematopoietic stem cells; Hematopoietic Stem Cells - drug effects; Hematopoietic Stem Cells - pathology; Humanities and Social Sciences; Humans; Interleukin-1beta - metabolism; Janus Kinase 2 - genetics; Kinases; letter; Mesenchymal Stromal Cells - drug effects; Mesenchymal Stromal Cells - pathology; Mice; multidisciplinary; Mutants; Mutation; Myeloproliferative disorders; Myeloproliferative Disorders - drug therapy; Myeloproliferative Disorders - pathology; Neoplasms - drug therapy; Neoplasms - pathology; Neoplastic Stem Cells - drug effects; Neoplastic Stem Cells - pathology; Nerve Fibers - drug effects; Nerve Fibers - pathology; Nestin - metabolism; Neuroprotective Agents - pharmacology; Neuroprotective Agents - therapeutic use; Peripheral nerve diseases; Receptors, Adrenergic, beta-3 - metabolism; Rodents; Schwann Cells - drug effects; Schwann Cells - pathology; Science; Stem Cell Niche; Stem cells; Studies; Sympathetic Nervous System - drug effects; Sympathetic Nervous System - pathology; Sympathetic Nervous System - physiopathology; Tumors; United States

Myeloproliferative neoplasms are caused by mutations in the haematopoietic stem cell (HSC) compartment, and here the authors show that the HSC niche contributes to the pathogenesis; sympathetic innervation of mesenchymal stem cells (MSCs) is reduced in the bone marrow of patients, which leads to red...