Interactome map uncovers phosphatidylserine transport by oxysterol-binding proteins

• Published in: Nature (London) Vol. 501; no. 7466; pp. 257 - 261
• Main Authors: Maeda, Kenji, Anand, Kanchan, Chiapparino, Antonella, Kumar, Arun, Poletto, Mattia, Kaksonen, Marko, Gavin, Anne-Claude
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 12.09.2013; Nature Publishing Group
• Subjects: 631/45/287/1192; 631/45/535/1266; 631/45/608; 631/553/2710; Binding proteins; Biological membranes; Biological Transport; Biosynthesis; Carrier Proteins - chemistry; Carrier Proteins - metabolism; Cell Membrane - metabolism; Dyslipidemias - metabolism; Endoplasmic Reticulum - metabolism; Eukaryotes; Fractionation; Homeostasis; Humanities and Social Sciences; Humans; Interactomes; letter; Ligands; Lipid metabolism; Lipids; Membranes; Metabolic disorders; Metabolic Syndrome - metabolism; multidisciplinary; Neoplasms - metabolism; Phosphatidylserines; Phosphatidylserines - metabolism; Phylogeny; Physiological aspects; Properties; Protein Interaction Maps; Proteins; Receptors, Steroid - chemistry; Receptors, Steroid - metabolism; Saccharomyces cerevisiae - metabolism; Saccharomyces cerevisiae Proteins - chemistry; Saccharomyces cerevisiae Proteins - metabolism; Science; Sterols; Substrate Specificity; Yeast; Yeasts; United States

The lipid-binding profiles of all lipid-transfer proteins in Saccharomyces cerevisiae are determined and a new subfamily of oxysterol-binding proteins that function in phosphatidylserine homeostasis and transport is identified. A novel family of phosphatidylserine transport proteins Eukaryotic cells...