Plant chitinase III Ziz m 1 stimulates multiple cytokines, most predominantly interleukin-13, from peripheral blood mononuclear cells of latex-fruit allergic patients

• Published in: Annals of Allergy, Asthma & Immunology Vol. 108; no. 2; pp. 113 - 116
• Main Authors: Lee, Mey-Fann, Lin, Shyh-Jye, Wang, Nancy M., Wu, Hsin-Ju, Chen, Yi-Hsing
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.02.2012; Elsevier BV; Elsevier
• Subjects: Adult; Allergens; Allergens - genetics; Allergens - immunology; Allergy and Immunology; Antigens, Plant; Biological and medical sciences; Cells, Cultured; Chitinases; Chitinases - genetics; Chitinases - immunology; Cloning, Molecular; Cross Reactions; Cytokines; Cytokines - biosynthesis; Dermatology; Escherichia coli; Escherichia coli - genetics; Female; Food Hypersensitivity; Food Hypersensitivity - immunology; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Humans; Interleukin-13; Interleukin-13 - biosynthesis; Interleukin-13 - genetics; Latex Hypersensitivity; Latex Hypersensitivity - immunology; Leukocytes, Mononuclear; Leukocytes, Mononuclear - immunology; Lymphocyte Activation; Male; Medical sciences; Middle Aged; Pichia; Pichia - genetics; Plant Proteins; Plant Proteins - genetics; Plant Proteins - immunology; Recombinant Proteins; Recombinant Proteins - genetics; Recombinant Proteins - immunology; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; Tetradecanoylphorbol Acetate; Tetradecanoylphorbol Acetate - analogs & derivatives; Tetradecanoylphorbol Acetate - immunology; Tetradecanoylphorbol Acetate - metabolism; Up-Regulation; Ziziphus; Ziziphus - immunology; Chitinase; Allergy; Hevea brasiliensis; Plant; Immunology; Mononuclear cell; Dicotyledones; Angiospermae; Euphorbiaceae; Human; Immunopathology; Multiple; Fruit; Nutrition; Enzyme; Dermatology; Cytokine; Natural rubber; Interleukin 13; Latex; Feeding; Glycosylases; Blood cell; Diet; Glycosidases; Hydrolases; Spermatophyta

Indian jujube is a fruit abundantly cultivated in Taiwan. Its major allergen in latex-fruit syndrome is Ziz m 1 of the chitinase III family. The Ziz m 1 Pichia (rZiz m 1-P) has chitinase activity but not Ziz m 1 E. coli (rZiz m 1-E). This study examined whether plant chitinase III, using rZiz m 1-P...