Estimation of Benchmark Dose for Pancreatic Damage in Cadmium-Exposed Smelters

• Published in: Toxicological sciences Vol. 97; no. 1; pp. 189 - 195
• Main Authors: Lei, Li-Jian, Chen, Liang, Jin, Tai-Yi, Nordberg, Monica, Chang, Xiu-Li
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.05.2007
• Subjects: Acetylglucosaminidase - urine; Adult; Albuminuria - chemically induced; Amylases - blood; benchmark dose; beta 2-Microglobulin - urine; biomarker; Biomarkers - blood; Biomarkers - urine; Body Burden; Cadmium - blood; Cadmium - toxicity; Cadmium - urine; cadmium exposure; Case-Control Studies; China; Dose-Response Relationship, Drug; endocrine; Female; Humans; Insulin - blood; Male; Medicin och hälsovetenskap; Metallurgy; Middle Aged; Occupational Diseases - chemically induced; Occupational Diseases - pathology; Occupational Exposure - adverse effects; pancreas; Pancreas - drug effects; Pancreas - metabolism; Pancreatic Diseases - blood; Pancreatic Diseases - chemically induced; Pancreatic Diseases - urine; Proteinuria - blood; Proteinuria - chemically induced; Proteinuria - urine; renal; Risk Assessment; China; renal; benchmark dose; cadmium exposure; biomarker; pancreas; endocrine
• ISSN: 1096-6080; 1096-0929; 1096-0929
• DOI: 10.1093/toxsci/kfm016

The aim of this study was to estimate the benchmark dose (BMD) for pancreas dysfunction caused by cadmium (Cd) exposure in smelters. Smelter workers who had been exposed to Cd for more than 1 year and matching nonoccupationally exposed subjects were asked to participate in this study. Urinary cadmium (UCd) was used as a biomarker for exposure, serum insulin and amylase were used as biomarkers for pancreatic effects. In this study, serum insulin and amylase were lower in the smelter workers than in the nonoccupationally exposed subjects. A significant dose-response relationship with UCd was displayed. BMDs in terms of urinary Cd corrected for creatinine were calculated by use of BMDS (version 1.3.2). The benchmark dose lower limit of a one-sided 95% confidence interval (BMDL) for 10% excess risk was also determined. It was found that the BMDL10 for serum insulin and serum amylase was 3.7 and 5.3 μg/g Cr, respectively. Compared to the BMDL for renal damage caused by Cd exposure, identified by the effect biomarkers urinary β2-microglobulin, urinary N-acetyl-β-glucosaminidase, and urinary albumin (UALB), it was shown that BMDL10 for serum insulin is the lowest among all values and UALB gave the highest value (5.8 μg/g Cr). This study indicates that Cd exposure can result in pancreatic dysfunction and the effect appears at lower urinary Cd level than renal dysfunction. The endocrine function of the pancreas was affected at lower urinary levels of Cd, compared to the exocrine function, which was seen at higher urinary levels of Cd than those giving rise to renal tubular dysfunction.