Ketamine blocks bursting in the lateral habenula to rapidly relieve depression

• Published in: Nature (London) Vol. 554; no. 7692; pp. 317 - 322
• Main Authors: Yang, Yan, Cui, Yihui, Sang, Kangning, Dong, Yiyan, Ni, Zheyi, Ma, Shuangshuang, Hu, Hailan
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 15.02.2018; Nature Publishing Group
• Subjects: 13; 42/41; 631/378/1457; 631/378/1689/1414; 631/378/2586; 64; 64/60; 64/86; 9/30; 9/74; Action Potentials - drug effects; Affect - drug effects; Anhedonia - drug effects; Animal models; Animals; Antidepressants; Antidepressive Agents - administration & dosage; Antidepressive Agents - pharmacology; Antidepressive Agents - therapeutic use; Bursting; Calcium Channel Blockers - pharmacology; Calcium Channel Blockers - therapeutic use; Calcium channels; Calcium channels (T-type); Calcium channels (voltage-gated); Calcium Channels - metabolism; Depression (Mood disorder); Depression - drug therapy; Disease Models, Animal; Firing pattern; Glutamate receptors; Habenula; Habenula - drug effects; Habenula - metabolism; Habenula - pathology; Habenula - radiation effects; Hedonic response; Humanities and Social Sciences; Ketamine; Ketamine - administration & dosage; Ketamine - pharmacology; Ketamine - therapeutic use; Luteinizing hormone; Male; Mental depression; Mental disorders; Mental health; Mice; Mood; multidisciplinary; N-Methyl-D-aspartic acid receptors; Neurons; Neurons - drug effects; Neurons - metabolism; Pharmacology; Physiological aspects; Pineal gland; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors; Receptors, N-Methyl-D-Aspartate - metabolism; Reinforcement; Reward; Rodents; Science; Synchronism; Synchronization; Theta Rhythm - drug effects

The N -methyl- d -aspartate receptor (NMDAR) antagonist ketamine has attracted enormous interest in mental health research owing to its rapid antidepressant actions, but its mechanism of action has remained elusive. Here we show that blockade of NMDAR-dependent bursting activity in the ‘anti-reward...