Alterations in cholesterol metabolism as a risk factor for developing Alzheimer’s disease: Potential novel targets for treatment

• Published in: The Journal of steroid biochemistry and molecular biology Vol. 190; pp. 104 - 114
• Main Authors: Loera-Valencia, Raúl, Goikolea, Julen, Parrado-Fernandez, Cristina, Merino-Serrais, Paula, Maioli, Silvia
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.06.2019; Elsevier BV
• Subjects: 27-Hydroxycholesterol; ACE inhibitors; Alzheimer's disease; Amyloid; Amyloid beta; Apolipoprotein; Astrocyte; Blood-brain barrier; Brain; Cerebral cholesterol; Cholesterol; Cholesterol 24S-hydroxylase; Cognitive ability; Cytochrome P-450; Dementia; Dementia disorders; Efavirenz; Hypercholesterolemia; Lipid; Lipid metabolism; Liver X activated receptor; Medicin och hälsovetenskap; Metabolism; Metabolites; Neurodegeneration; Neurodegenerative diseases; Neurofibrillary tangles; Oxysterols; PSD95; RXR; Senile plaques; Statins; Liver X activated receptor; Alzheimer’s disease; Cytochrome P-450; Cerebral cholesterol; Cholesterol 24S-hydroxylase; Apolipoprotein; Astrocyte; RXR; Efavirenz; Lipid; Amyloid beta; PSD95; Neurodegeneration; Oxysterols; 27-Hydroxycholesterol; ACE inhibitors; Statins; Dementia

Alzheimer's disease (AD) is the most common form of dementia and it is characterized by the deposition of amyloid-β (Aβ) plaques and neurofibrillary tangles in the brain. However, the complete pathogenesis of the disease is still unknown. High level of serum cholesterol has been found to positi...