Structural basis for inhibition of the SARS-CoV-2 RNA polymerase by suramin - Yin, Wanchao; Luan, Xiaodong; Li, Zhihai; Zhou, Ziwei; Wang, Qingxing; Gao, Minqi; Wang, Xiaoxi; Zhou, Fulai; Shi, Jingjing; You, Erli; Liu, Mingliang; Wang, Qingxia; et al. (Nature structural & molecular biology, 2021)
Keywords: 101/28; 631/154; 631/535/1258; 82/80; 82/83; Animals; Antiparasitic agents; Antiviral Agents - chemistry; Antiviral Agents - metabolism; Antiviral Agents - pharmacology; Binding Sites; Biochemistry; Biological Microscopy; Biomedical and Life Sciences; Catalytic Domain; Chemical properties; Chlorocebus aethiops; Coronavirus RNA-Dependent RNA Polymerase - antagonists & inhibitors; Coronavirus RNA-Dependent RNA Polymerase - chemistry; Coronavirus RNA-Dependent RNA Polymerase - metabolism; Coronaviruses; COVID-19; Cryoelectron Microscopy; DNA-directed RNA polymerase; Electron microscopy; Enzyme binding; Enzyme Inhibitors - chemistry; Enzyme Inhibitors - metabolism; Enzyme Inhibitors - pharmacology; Health aspects; Inhibitors; Life Sciences; Membrane Biology; Nucleotides; Pandemics; Pharmacology, Experimental; Protein Conformation; Protein Structure; RNA polymerase; RNA polymerases; RNA, Viral - chemistry; RNA, Viral - metabolism; RNA-directed RNA polymerase; SARS-CoV-2 - drug effects; Severe acute respiratory syndrome coronavirus 2; Structure; Suramin; Suramin - chemistry; Suramin - metabolism; Suramin - pharmacology; Suramin sodium; Vero Cells; Viral diseases; Virus Replication - drug effects; China