Sputum neutrophil counts are associated with more severe asthma phenotypes using cluster analysis

• Published in: Journal of allergy and clinical immunology Vol. 133; no. 6; pp. 1557 - 1563.e5
• Main Authors: Moore, Wendy C., Hastie, Annette T., Li, Xingnan, Li, Huashi, Busse, William W., Jarjour, Nizar N., Wenzel, Sally E., Peters, Stephen P., Meyers, Deborah A., Bleecker, Eugene R.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.06.2014; Elsevier; Elsevier Limited
• Subjects: Adolescent; Adult; Age; Age Factors; Allergy and Immunology; Asthma; Asthma - blood; Asthma - diagnosis; Asthma - physiopathology; Biological and medical sciences; Body mass index; Cluster Analysis; Colleges & universities; Discriminant analysis; eosinophils; Family medical history; Female; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Granulocytes; Humans; Immunopathology; Leukocyte Count; Male; Medical sciences; Middle Aged; Multivariate analysis; Neutrophils; Phenotype; Respiratory Function Tests; Risk Factors; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; severe asthma; Severe Asthma Research Program; Severity of Illness Index; sputum; Sputum - cytology; Statistical methods; Young Adult; phenotype; ATS; eosinophils; sputum; SARP; Severe Asthma Research Program; FVC; severe asthma; ICS; HCU; cluster analysis; neutrophils; OCS; BMI; Forced vital capacity; Inhaled corticosteroid; Oral corticosteroid; American Thoracic Society; Body mass index; Health care utilization; Immunopathology; Granulocyte; Eosinophil; Numeration; Phenotype; Association; Immunology; Research program; Sputum; Neutrophil; Severe asthma

Clinical cluster analysis from the Severe Asthma Research Program (SARP) identified 5 asthma subphenotypes that represent the severity spectrum of early-onset allergic asthma, late-onset severe asthma, and severe asthma with chronic obstructive pulmonary disease characteristics. Analysis of induced...