Identification and DNA sequence analysis of the Marek's disease virus serotype 2 genes homologous to the herpes simplex virus type 1 UL20 and UL21

We determined 3, 135 bp of the nucleotide sequence located in an 8.5 kb EcoRI-E fragment in the unique long (UL) genome region of Marek's disease virus serotype 2 (MDV2), and identified UL20 and UL21 homologous genes of herpes simplex virus type 1 (HSV-1). The UL20 and UL21 homologous genes of...

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Published in	Journal of Veterinary Medical Science Vol. 61; no. 6; pp. 587 - 593
Main Authors	Hatama, S. (Tokyo Univ. (Japan)), Jang, H.K, Izumiya, Y, Cai, J.S, Tsushima, Y, Kato, K, Miyazawa, T, Kai, C, Takahashi, E, Mikami, T
Format	Journal Article
Language	English
Published	Japan JAPANESE SOCIETY OF VETERINARY SCIENCE 01.06.1999 Japan Science and Technology Agency
Subjects	ADN Amino Acid Sequence Base Sequence CHICKENS DNA GENE GENES Genetic Vectors Genome, Viral Herpes simplex virus 1 Herpesvirus Herpesvirus 1, Human - genetics Herpesvirus 2, Gallid - classification Herpesvirus 2, Gallid - genetics HERPETOVIRIDAE Marek's disease herpesvirus MAREK'S DISEASE VIRUS Marek's disease virus serotype 2 Molecular Sequence Data NUCLEOTIDE SEQUENCE ORF 273 POLLO POULET SECUENCIA NUCLEOTIDICA Sequence Analysis, DNA SEQUENCE NUCLEOTIDIQUE SEROTIPOS SEROTYPE SEROTYPES Serotyping UL20 UL21 Viral Proteins - genetics VIRUS ENFERMEDAD DE MAREK VIRUS MALADIE DE MAREK
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ISSN	0916-7250 1347-7439
DOI	10.1292/jvms.61.587

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Abstract	We determined 3, 135 bp of the nucleotide sequence located in an 8.5 kb EcoRI-E fragment in the unique long (UL) genome region of Marek's disease virus serotype 2 (MDV2), and identified UL20 and UL21 homologous genes of herpes simplex virus type 1 (HSV-1). The UL20 and UL21 homologous genes of MDV2 are arranged colinearly with the prototype sequence of HSV-1. In addition, an open reading frame (MDV2 ORF 273), which has been identified within the UL21 homologous gene of MDV2, has no apparent relation to any other known herpesvirus genes. Northern blot analysis and reverse transcriptase polymerase chain reaction confirmed the existance of RNA transcripts related to the UL20 and ORF 273 genes in MDV2-infected cells, except no transcript related to the UL21 gene being detected. The putative protein product of the MDV2 UL20 gene had a relatively low homology but that of the MDV2 UL21 gene had a moderate homology among herpesviruses. Further, the possible functions and features of the predicted proteins encoded within the sequenced region are discussed.
AbstractList	We determined 3, 135 bp of the nucleotide sequence located in an 8.5 kb EcoRI-E fragment in the unique long (UL) genome region of Marek's disease virus serotype 2 (MDV2), and identified UL20 and UL21 homologous genes of herpes simplex virus type 1 (HSV-1). The UL20 and UL21 homologous genes of MDV2 are arranged colinearly with the prototype sequence of HSV-1. In addition, an open reading frame (MDV2 ORF 273), which has been identified within the UL21 homologous gene of MDV2, has no apparent relation to any other known herpesvirus genes. Northern blot analysis and reverse transcriptase polymerase chain reaction confirmed the existance of RNA transcripts related to the UL20 and ORF 273 genes in MDV2-infected cells, except no transcript related to the UL21 gene being detected. The putative protein product of the MDV2 UL20 gene had a relatively low homology but that of the MDV2 UL21 gene had a moderate homology among herpesviruses. Further, the possible functions and features of the predicted proteins encoded within the sequenced region are discussed. We determined 3,135 bp of the nucleotide sequence located in an 8.5 kb EcoRI-E fragment in the unique long (UL) genome region of Marek's disease virus serotype 2 (MDV2), and identified UL20 and UL21 homologous genes of herpes simplex virus type 1 (HSV-1). The UL20 and UL21 homologous genes of MDV2 are arranged colinearly with the prototype sequence of HSV-1. In addition, an open reading frame (MDV2 ORF 273), which has been identified within the UL21 homologous gene of MDV2, has no apparent relation to any other known herpesvirus genes. Northern blot analysis and reverse transcriptase polymerase chain reaction confirmed the existance of RNA transcripts related to the UL20 and ORF 273 genes in MDV2-infected cells, except no transcript related to the UL21 gene being detected. The putative protein product of the MDV2 UL20 gene had a relatively low homology but that of the MDV2 UL21 gene had a moderate homology among herpesviruses. Further, the possible functions and features of the predicted proteins encoded within the sequenced region are discussed.We determined 3,135 bp of the nucleotide sequence located in an 8.5 kb EcoRI-E fragment in the unique long (UL) genome region of Marek's disease virus serotype 2 (MDV2), and identified UL20 and UL21 homologous genes of herpes simplex virus type 1 (HSV-1). The UL20 and UL21 homologous genes of MDV2 are arranged colinearly with the prototype sequence of HSV-1. In addition, an open reading frame (MDV2 ORF 273), which has been identified within the UL21 homologous gene of MDV2, has no apparent relation to any other known herpesvirus genes. Northern blot analysis and reverse transcriptase polymerase chain reaction confirmed the existance of RNA transcripts related to the UL20 and ORF 273 genes in MDV2-infected cells, except no transcript related to the UL21 gene being detected. The putative protein product of the MDV2 UL20 gene had a relatively low homology but that of the MDV2 UL21 gene had a moderate homology among herpesviruses. Further, the possible functions and features of the predicted proteins encoded within the sequenced region are discussed.
Author	Miyazawa, T Mikami, T Cai, J.S Jang, H.K Kato, K Takahashi, E Hatama, S. (Tokyo Univ. (Japan)) Tsushima, Y Izumiya, Y Kai, C
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The glycoprotein genes of Marek's disease virus serotype 2 and 3: identification and expression by recombinant fowlpox virus. Virology 200: 484-493. 12) Jang, H.-K., Niikura, M., Song, C.-S. and Mikami, T. 1997. Characterization and expression of the Marek's disease virus serotype 2 glycoprotein E in recombinant baculovirus-infected cells: initial analysis of its DNA sequence and antigenic properties. Virus Res. 48: 111-123. 22) Schat, K. A., Calnek, B. W. and Fabricant, J. 1982. Characterization of two highly oncogenic strains of Marek's disease virus. Avian Pathol. 11: 593-606. 16) Klupp, B. G., Kern, H. and Mettenleiter, T. C. 1992. The virulence determining genomic BamHI fragment 4 of pseudorabies virus contains genes corresponding to the UL15 (partial), UL18, UL19, UL20, and UL21 genes of herpes simplex virus and a putative origin of replication. Virology 191: 900-908. 18) McGeoch, D. J., Dalrymple, M. A., Davison, A. J., Dolan, A., Frame, M. C., McNab, D., Perry, L. J., Scott, J. E. and Taylor, P. 1988. The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1. J. Gen. Virol. 69: 1531-1574. 23) Sheldrick, P. and Berthelot, N. 1975. Inverted repetitions in the chromosome of herpes simplex virus. Cold Spring Harbor Symp. Quant. Biol. 39: 667-678. 19) Ono, M., Kawaguchi, Y., Maeda, K., Kamiya, N., Tohya, Y., Kai, C., Niikura, M. and Mikami, T. 1994. Nucleotide sequence analysis of Marek's disease virus (MDV) serotype 2 homolog of MDV serotype 1 pp38, an antigen associated with transformed cells. Virology 201: 142-146. 5) Buckmaster, A. E., Scott S. D., Sanderson, M. J., Boursnell, M. E. G., Ross, L. J. N. and Binns, M. M. 1988. Gene sequence and mapping data from Marek's disease virus and herpesvirus of turkeys: implications for herpesvirus classification. J. Gen. Virol. 69: 2033-2042. 28) Ward, P. L., Campadelli-Fiume, G., Avitable, E. and Roizman, B. 1994. Localization and putative function of the UL20 membrane protein in cells infected with herpes simplex virus 1. J. Virol. 68: 7406-7417. 26) Silva, R. F. and Barnett, J. C. 1991. Restriction endonuclease analysis of Marek's disease virus DNA: differentiation of viral strains and determination of passage history. Avian Dis. 35: 487-495. 10) Hirai, K., Nakajima, K., Ikuta, K., Kirisawa, R., Kawakami, Y., Mikami, T. and Kato, S. 1986. Similarities and dissimilarities in the structure and expression of viral genomes of various virus strains immunologically related to Marek's disease virus. Arch. Virol. 89: 113-130. 15) Kitazawa, T., Ono, M., Maeda, K., Kawaguchi, Y., Kamiya, N., Niikura, M. and Mikami, T. 1993. Nucleotide sequence of glycoprotein C (gC) homologous gene of Marek's disease virus (MDV) serotype 2 and comparison of gC homologous genes among three serotypes of MDV. J. Vet. Med. Sci. 55: 985-990. 1) Baines, J. D., Koyama, A. H., Huang, T. and Roizman, B. 1994. The UL21 gene products of herpes simplex virus 1 are dispensable for growth in cultured cells. J. Virol. 68: 2929-2936. 17) Kyte, J. and Doolittle, R. F. 1982. A simple method for displaying the hydropathic character of a protein. J. Mol. Biol. 157: 105-132. 31) Vlcek, C., Benes, V., Lu, Z., Kutish, G. F., Paces, V., Rock, D., Letchworth, G. J. and Schwyzer, M. 1995. Nucleotide sequence analysis of a 30-kb region of the bovine herpesvirus 1 genome which exhibits a colinear gene arrangement with the UL21 to UL4 genes of herpes simplex virus. Virology 210: 100-108. 6) Davison, A. J. and Scott, J. E. 1986. The complete DNA sequence of varicella-zoster virus. J. Gen. Virol. 67: 1759-1816. 7) De Wind, N., Wagenaar, F., Pol, J., Kimman, T. and Berns, A. 1992. The pseudorabies virus homologue of the herpes simplex virus UL21 gene product is a capsid protein which is involved in capsid maturation. J. Virol. 66: 7096-7103. 8) Hayward, G. S., Jacob, R. J., Wadsworth, S. C. and Roizman, B. 1975. Anatomy of herpes simplex virus DNA: evidence for four populations of molecules that differ in the relative orientations of their long and short segments. Proc. Natl. Acad. Sci. U.S.A. 72: 4243-4247. 24) Shimojima, Y., Jang, H.-K., Ono, M., Kai, C. and Mikami, T. 1997. Identification and DNA sequence analysis of the Marek's disease virus serotype 2 genes homologous to the herpes simplex virus type 1 glycoprotein H. J. Vet. Med. Sci. 59: 629-634. 22 23 24 25 26 27 28 29 30 31 10 11 12 13 14 15 16 17 18 19 1 2 3 4 5 6 7 8 9 20 21
References_xml	– reference: 15) Kitazawa, T., Ono, M., Maeda, K., Kawaguchi, Y., Kamiya, N., Niikura, M. and Mikami, T. 1993. Nucleotide sequence of glycoprotein C (gC) homologous gene of Marek's disease virus (MDV) serotype 2 and comparison of gC homologous genes among three serotypes of MDV. J. Vet. Med. Sci. 55: 985-990. – reference: 21) Ross, L. J. N., Milne, B. and Biggs, P. M. 1983. Restriction endonuclease analysis of Marek's disease virus DNA and homology between strains. J. Gen. Virol. 64: 2785-2790. – reference: 24) Shimojima, Y., Jang, H.-K., Ono, M., Kai, C. and Mikami, T. 1997. Identification and DNA sequence analysis of the Marek's disease virus serotype 2 genes homologous to the herpes simplex virus type 1 glycoprotein H. J. Vet. Med. Sci. 59: 629-634. – reference: 26) Silva, R. F. and Barnett, J. C. 1991. Restriction endonuclease analysis of Marek's disease virus DNA: differentiation of viral strains and determination of passage history. Avian Dis. 35: 487-495. – reference: 3) Baer, R., Bankier, A. T., Biggin, M. D., Deininger, P. L., Farrell, P. J., Gibson, T. J., Hatfull, G., Hudson, G. S., Satchwell, S. C., Seguin, C., Tuffnell, P. S. and Barrell, B. G. 1984. DNA sequence and expression of the B95-8 Epstein-Barr virus genome. Nature 310: 207-211. – reference: 30) Yoshida, S., Lee, L. F., Yanagida, N. and Nazarian, K. 1994. The glycoprotein genes of Marek's disease virus serotype 2 and 3: identification and expression by recombinant fowlpox virus. Virology 200: 484-493. – reference: 5) Buckmaster, A. E., Scott S. D., Sanderson, M. J., Boursnell, M. E. G., Ross, L. J. N. and Binns, M. M. 1988. Gene sequence and mapping data from Marek's disease virus and herpesvirus of turkeys: implications for herpesvirus classification. J. Gen. Virol. 69: 2033-2042. – reference: 1) Baines, J. D., Koyama, A. H., Huang, T. and Roizman, B. 1994. The UL21 gene products of herpes simplex virus 1 are dispensable for growth in cultured cells. J. Virol. 68: 2929-2936. – reference: 18) McGeoch, D. J., Dalrymple, M. A., Davison, A. J., Dolan, A., Frame, M. C., McNab, D., Perry, L. J., Scott, J. E. and Taylor, P. 1988. The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1. J. Gen. Virol. 69: 1531-1574. – reference: 4) Blaho, J. A., Mitchell, C. and Roizman, B. 1994. An amino acid sequence shared by the herpes simplex virus 1 a regulatory proteins 0, 4, 22 and 27 predicts the nucleotidylylation of the UL21, UL31, UL47 and UL49 gene products. J. Biol. Chem. 269: 17401-17410. – reference: 22) Schat, K. A., Calnek, B. W. and Fabricant, J. 1982. Characterization of two highly oncogenic strains of Marek's disease virus. Avian Pathol. 11: 593-606. – reference: 13) Jang, H.-K., Ono, M., Kato, Y., Tohya, Y., Niikura, M. and Mikami, T. 1996. 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The pseudorabies virus homologue of the herpes simplex virus UL21 gene product is a capsid protein which is involved in capsid maturation. J. Virol. 66: 7096-7103. – reference: 28) Ward, P. L., Campadelli-Fiume, G., Avitable, E. and Roizman, B. 1994. Localization and putative function of the UL20 membrane protein in cells infected with herpes simplex virus 1. J. Virol. 68: 7406-7417. – reference: 8) Hayward, G. S., Jacob, R. J., Wadsworth, S. C. and Roizman, B. 1975. Anatomy of herpes simplex virus DNA: evidence for four populations of molecules that differ in the relative orientations of their long and short segments. Proc. Natl. Acad. Sci. U.S.A. 72: 4243-4247. – reference: 25) Shimojima, Y., Jang, H.-K., Ono M., Maeda, K., Tohya, Y. and Mikami, T. 1997. Identification and DNA sequence analysis of the Marek's disease virus serotype 2 genes homologous to the thymidine kinase and UL24 genes of herpes simplex virus type 1. 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Snippet	We determined 3, 135 bp of the nucleotide sequence located in an 8.5 kb EcoRI-E fragment in the unique long (UL) genome region of Marek's disease virus... We determined 3,135 bp of the nucleotide sequence located in an 8.5 kb EcoRI-E fragment in the unique long (UL) genome region of Marek's disease virus serotype...
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SubjectTerms	ADN Amino Acid Sequence Base Sequence CHICKENS DNA GENE GENES Genetic Vectors Genome, Viral Herpes simplex virus 1 Herpesvirus Herpesvirus 1, Human - genetics Herpesvirus 2, Gallid - classification Herpesvirus 2, Gallid - genetics HERPETOVIRIDAE Marek's disease herpesvirus MAREK'S DISEASE VIRUS Marek's disease virus serotype 2 Molecular Sequence Data NUCLEOTIDE SEQUENCE ORF 273 POLLO POULET SECUENCIA NUCLEOTIDICA Sequence Analysis, DNA SEQUENCE NUCLEOTIDIQUE SEROTIPOS SEROTYPE SEROTYPES Serotyping UL20 UL21 Viral Proteins - genetics VIRUS ENFERMEDAD DE MAREK VIRUS MALADIE DE MAREK
Title	Identification and DNA sequence analysis of the Marek's disease virus serotype 2 genes homologous to the herpes simplex virus type 1 UL20 and UL21
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