The mechanism of enriched environment repairing the learning and memory impairment in offspring of prenatal stress by regulating the expression of activity-regulated cytoskeletal-associated and insulin-like growth factor-2 in hippocampus

• Published in: Environmental health and preventive medicine Vol. 26; no. 1; pp. 8 - 12
• Main Authors: Guan, Su-zhen, Fu, You-juan, Zhao, Feng, Liu, Hong-ya, Chen, Xiao-hui, Qi, Fa-qiu, Liu, Zhi-hong, Ng, Tzi Bun
• Format: Journal Article
• Language: English
• Published: England Komiyama Printing Co., Ltd 15.01.2021; BioMed Central; Komiyama Printing Co. Ltd
• Subjects: Abnormalities; Activity-regulated cytoskeletal-associated protein (Arc); Animal cognition; Animals; Behavior; Cognitive ability; Corticosterone; Cytoskeletal Proteins - genetics; Cytoskeletal Proteins - metabolism; Cytoskeleton; Enriched environment; Enrichment; Environmental factors; Environmental health; Female; Fetuses; Gene expression; Gene Expression Regulation; Growth factors; Hippocampus; Hippocampus - metabolism; Hormones; Hypotheses; Impairment; Insulin; Insulin-like growth factor 2 (IGF-2); Insulin-Like Growth Factor II - genetics; Insulin-Like Growth Factor II - metabolism; Insulin-like growth factors; Laboratories; Learning; Learning and memory; Learning Disabilities - genetics; Learning Disabilities - psychology; Male; Maze learning; Memory; Memory Disorders - genetics; Memory Disorders - psychology; mRNA; Nerve Tissue Proteins - genetics; Nerve Tissue Proteins - metabolism; Offspring; Polymerase chain reaction; Pregnancy; Prenatal experience; Prenatal Exposure Delayed Effects - genetics; Prenatal Exposure Delayed Effects - psychology; Prenatal stress; Proteins; Random Allocation; Rats; Rats, Wistar; Social Environment; Stress; Stress, Psychological - genetics; Su-zhen Guan and You-juan Fu are coauthors of the paper; Western blotting; Learning and memory; Insulin-like growth factor 2 (IGF-2); Activity-regulated cytoskeletal-associated protein (Arc); Su-zhen Guan and You-juan Fu are coauthors of the paper; Enriched environment; Prenatal stress

Prenatal stress can cause neurobiological and behavioral defects in offspring; environmental factors play a crucial role in regulating the development of brain and behavioral; this study was designed to test and verify whether an enriched environment can repair learning and memory impairment in offs...