Myeloid-derived suppressor cells: more mechanisms for inhibiting antitumor immunity

• Published in: Cancer Immunology, Immunotherapy Vol. 59; no. 10; pp. 1593 - 1600
• Main Author: Ostrand-Rosenberg, Suzanne
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Berlin/Heidelberg : Springer-Verlag 01.10.2010; Springer-Verlag; Springer; Springer Nature B.V
• Subjects: amino acid metabolism; Animals; Antigens; Antineoplastic agents; Biological and medical sciences; Cancer; Cancer Research; Cancer Vaccines; CD8-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes - immunology; Cells; Focussed Research Review; Humans; Immunology; Immunotherapy; Lymphatic system; Lymphocytes; Medical sciences; Medicine; Medicine & Public Health; Myeloid Cells; Myeloid Cells - immunology; Oncology; Pharmacology. Drug treatments; Suppressive myeloid cells; T cell trafficking; Tumor-induced immune suppression; Tumors; Suppressive myeloid cells; Tumor-induced immune suppression; T cell trafficking; Amino acid metabolism; Antineoplastic agent; Myeloid derived suppressor cell; Malignant tumor; Metabolism; Myeloid cell; Immunity; Immunosuppression; Treatment; Aminoacid; Immunotherapy; T-Lymphocyte; Suppressive cell; Pharmacokinetics; Mechanism of action; Cell migration; Cancer

Myeloid-derived suppressor cells (MDSC) accumulate in most cancer patients and experimental animals with cancer. They accumulate in response to pro-inflammatory mediators and they use a variety of mechanisms to block both innate and adaptive antitumor immunity. Because of their critical role in obst...