pUL21 regulation of pUs3 kinase activity influences the nature of nuclear envelope deformation by the HSV-2 nuclear egress complex

• Published in: PLoS pathogens Vol. 17; no. 8; p. e1009679
• Main Authors: Muradov, Jamil H., Finnen, Renée L., Gulak, Michael A., Hay, Thomas J. M., Banfield, Bruce W.
• Format: Journal Article
• Language: English
• Published: San Francisco, CA USA Public Library of Science 23.08.2021; Public Library of Science (PLoS)
• Subjects: Biology and Life Sciences; Genetic aspects; Herpes simplex virus; Medicine and Health Sciences; Membrane proteins; Physiological aspects; Protein kinases; Research and Analysis Methods; Structure; Viral envelopes; Viral proteins; Canada

It is well established that the herpesvirus nuclear egress complex (NEC) has an intrinsic ability to deform membranes. During viral infection, the membrane-deformation activity of the NEC must be precisely regulated to ensure efficient nuclear egress of capsids. One viral protein known to regulate h...