Intracellular Reverse Transcription of Pfizer BioNTech COVID-19 mRNA Vaccine BNT162b2 In Vitro in Human Liver Cell Line

• Published in: Current issues in molecular biology Vol. 44; no. 3; pp. 1115 - 1126
• Main Authors: Aldén, Markus, Olofsson Falla, Francisko, Yang, Daowei, Barghouth, Mohammad, Luan, Cheng, Rasmussen, Magnus, De Marinis, Yang
• Format: Journal Article
• Language: English
• Published: MDPI 25.02.2022; MDPI AG
• Subjects: Basic Medicine; BNT162b2; Cell and Molecular Biology; Cell- och molekylärbiologi; COVID-19 mRNA vaccine; Huh7; LINE-1; Liver; Medical and Health Sciences; Medicin och hälsovetenskap; Medicinska och farmaceutiska grundvetenskaper; Reverse transcription

Preclinical studies of COVID-19 mRNA vaccine BNT162b2, developed by Pfizer and BioNTech, showed reversible hepatic effects in animals that received the BNT162b2 injection. Furthermore, a recent study showed that SARS-CoV-2 RNA can be reverse-transcribed and integrated into the genome of human cells....