A sensitive and rapid ultra HPLC–MS/MS method for the simultaneous detection of clopidogrel and its derivatized active thiol metabolite in human plasma - Peer, Cody J.; Spencer, Shawn D.; VanDenBerg, Dustin A.H.; Pacanowski, Michael A.; Horenstein, Richard B.; Figg, William D. (Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2012)
Keywords: Active metabolite; Analysis; Analytical, structural and metabolic biochemistry; Biological and medical sciences; Blood; Chromatography; Chromatography, High Pressure Liquid - methods; Clopidogrel; derivatization; Drug Stability; Elution; Fundamental and applied biological sciences. Psychology; General pharmacology; Human; Humans; Ionization; liquid chromatography; Materials handling; Medical sciences; Metabolites; pharmacokinetics; Pharmacology. Drug treatments; Reproducibility of Results; Run time (computers); Sensitivity and Specificity; Sulfhydryl Compounds - blood; Sulfhydryl Compounds - pharmacokinetics; tandem mass spectrometry; Tandem Mass Spectrometry - methods; thiols; Ticlopidine - analogs & derivatives; Ticlopidine - blood; Ticlopidine - chemistry; Ticlopidine - pharmacokinetics; Ultra HPLC–MS/MS; LLOQ; QC; uHPLC; MS; Clopidogrel; Active metabolite; Ultra HPLC–MS/MS; CAMD; MS/MS; EDTA; MPB; Human; Ultra performance liquid chromatography; Biological fluid; Thiol; Metabolite; Ultra HPLC-MS/MS; HPLC chromatography; Derivatization; Antiplatelet agent; Blood plasma; Simultaneous measurement; Antithrombotic agent; Thienopyridine derivative