Multiple Myeloma Disrupts the TRANCE/Osteoprotegerin Cytokine Axis to Trigger Bone Destruction and Promote Tumor Progression

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 98; no. 20; pp. 11581 - 11586
• Main Authors: Pearse, Roger N., Sordillo, Emilia M., Yaccoby, Shmuel, Wong, Brian R., Liau, Deng F., Colman, Neville, Michaeli, Joseph, Epstein, Joshua, Choi, Yongwon
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 25.09.2001; National Acad Sciences; The National Academy of Sciences
• Subjects: Acid Phosphatase - metabolism; Animals; Antibodies; Biological Sciences; Bone marrow; Bones; Carrier Proteins - antagonists & inhibitors; Carrier Proteins - genetics; Carrier Proteins - metabolism; Cell lines; Cells; Coculture techniques; Cytokines; Disease Progression; Genetics; Glycoproteins - antagonists & inhibitors; Glycoproteins - genetics; Glycoproteins - pharmacology; Heterologous transplantation; Hodgkin Disease - pathology; Humans; Isoenzymes - metabolism; Leukemia, Lymphocytic, Chronic, B-Cell - pathology; Membrane Glycoproteins - antagonists & inhibitors; Membrane Glycoproteins - genetics; Membrane Glycoproteins - metabolism; Mice; Mice, SCID; Multiple myeloma; Osteoprotegerin; Paraproteinemias - pathology; Plasma cells; RANK Ligand; Receptor Activator of Nuclear Factor-kappa B; Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors; Receptors, Cytoplasmic and Nuclear - genetics; Receptors, Tumor Necrosis Factor; Reference Values; Reverse Transcriptase Polymerase Chain Reaction; Stromal cells; Studies; Tartrate-Resistant Acid Phosphatase; Time Factors; TRANCE protein; Tumors

Bone destruction, caused by aberrant production and activation of osteoclasts, is a prominent feature of multiple myeloma. We demonstrate that myeloma stimulates osteoclastogenesis by triggering a coordinated increase in the tumor necrosis factor-related activation-induced cytokine (TRANCE) and decr...