Multiple Myeloma Disrupts the TRANCE/Osteoprotegerin Cytokine Axis to Trigger Bone Destruction and Promote Tumor Progression - Pearse, Roger N.; Sordillo, Emilia M.; Yaccoby, Shmuel; Wong, Brian R.; Liau, Deng F.; Colman, Neville; Michaeli, Joseph; Epstein, Joshua; Choi, Yongwon (Proceedings of the National Academy of Sciences - PNAS, 2001)
Keywords: Acid Phosphatase - metabolism; Animals; Antibodies; Biological Sciences; Bone marrow; Bones; Carrier Proteins - antagonists & inhibitors; Carrier Proteins - genetics; Carrier Proteins - metabolism; Cell lines; Cells; Coculture techniques; Cytokines; Disease Progression; Genetics; Glycoproteins - antagonists & inhibitors; Glycoproteins - genetics; Glycoproteins - pharmacology; Heterologous transplantation; Hodgkin Disease - pathology; Humans; Isoenzymes - metabolism; Leukemia, Lymphocytic, Chronic, B-Cell - pathology; Membrane Glycoproteins - antagonists & inhibitors; Membrane Glycoproteins - genetics; Membrane Glycoproteins - metabolism; Mice; Mice, SCID; Multiple myeloma; Osteoprotegerin; Paraproteinemias - pathology; Plasma cells; RANK Ligand; Receptor Activator of Nuclear Factor-kappa B; Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors; Receptors, Cytoplasmic and Nuclear - genetics; Receptors, Tumor Necrosis Factor; Reference Values; Reverse Transcriptase Polymerase Chain Reaction; Stromal cells; Studies; Tartrate-Resistant Acid Phosphatase; Time Factors; TRANCE protein; Tumors