Amino acid T25 in the substrate-binding domain of SARS-CoV-2 nsp5 is involved in viral replication in the mouse lung - Sugiura, Yoshiro; Shimizu, Kenta; Takahashi, Tatsuki; Ueno, Shiori; Tanigou, Haruka; Amarbayasgalan, Sodbayasgalan; Kamitani, Wataru (PloS one, 2024)
Keywords: Acclimation; Acclimatization; Amino acids; Animals; Antibodies; Artificial chromosomes; Bacterial artificial chromosomes; Binding; Cell culture; Chlorocebus aethiops; Chromosomes; Coronaviruses; COVID-19; COVID-19 - metabolism; COVID-19 - virology; Cysteine proteinase; Drug resistance; Enzymes; Experiments; Female; Health aspects; Humans; Immune system; Lung - metabolism; Lung - pathology; Lung - virology; Lungs; Mice; Mice, Inbred BALB C; Mutation; Pathogenesis; Plasmids; Polymerase chain reaction; Protease; Protein Domains; Proteins; Reagents; Replication; SARS-CoV-2 - genetics; SARS-CoV-2 - metabolism; SARS-CoV-2 - pathogenicity; SARS-CoV-2 - physiology; Severe acute respiratory syndrome coronavirus 2; Vero Cells; Viral diseases; Viral Load; Viral Nonstructural Proteins - genetics; Viral Nonstructural Proteins - metabolism; Virus Replication; Viruses; Weight loss; Japan; United States--US